TITLE:
Antioxidant and Neuroprotective Activities of the Mesocarp of Raphia hookeri Fruit against Aluminum Chloride-Induced Neurotoxicity in Rats
AUTHORS:
Hermine Tsafack Doungue, Anne Pascale Nouemsi Kengne, Hilaire Marcaire Womeni
KEYWORDS:
Raphia hookeri, Phenolic Compounds, Rats, Aluminium Chloride, Antioxidant, Neuroprotective Effect
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.11 No.5,
May
20,
2020
ABSTRACT: This work aims to evaluate the antioxidant and protective effect of Raphia hookeri (Rh) fruit extracts and powders against aluminum induced neurotoxicity in
rats. Extracts and powder were prepared using fruit mesocarp. Phytochemical
contents (phenolic content and flavonoïd) and antioxidant in vitro activity were evaluated through the DPPH radical scavenging capacity,
the ability to reduce ferric ion and Hydroxyl radical scavenging ability. The
neurocognitive dysfunction, the activity of acetylcholinesterase (AChE) and
activities of antioxidant in vivo indices were evaluated in the plasma, liver and brain of aluminum
chloride (AlCl3) induced neurotoxicity in rats. The
highest total phenolic (76.34 mg Eq AG/g of extract), flavonoïds’
contents (13.32 mg Eq CAT/g of extract), the best DPPH scavenging activity and
the ability to reduce ferric ion (Fe3+) were obtained with aqueous
extract. The administration of aqueous extract (200 and 400 g/kg bw) and powder
(5% and 10 %) during 28 days resulted in a significant decrease (P Treatment
with aqueous extract and powder of Rh mesocarp ameliorated neurobehavioral
changes by enhancing antioxidant activities, cognitive functions. Therefore Rh would
protect oxidative damage and preserve neurone functions.