TITLE:
Comparison of Age and Gender Differences of Tryptophan Metabolites in Patients of Major Monopolar and Bipolar Depression
AUTHORS:
Hiroi Tomioka, Junichi Masuda, Akikazu Takada, Akira Iwanami
KEYWORDS:
Depression, Monopolar Depression, Bipolar Depression, Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, Kynurenine, 3-Hydroxykynurenine, Kynurenic Acid, Anthranilic Acid, Xanthurenic Acid, Indole-3-Acetic Acid, SSRI (Selective Serotonin Reuptake Inhibitor), SNRI (Serotonin Norepinephrine Reuptake Inhibitor), Anxiolytic, Antipsychotic
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.11 No.3,
March
5,
2020
ABSTRACT: Background: No research has been done for the determination of
plasma levels of tryptophan metabolites in patients of monopolar and bipolar
depression. Methods: Ultra high-speed liquid chromatography/mass
spectrometry has been used for the simultaneous determination of plasma levels
of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were
shown in monopolar depressive patients and some differences were shown in
bipolar patients. The administration of drugs such as antidepressants,
antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of
plasma levels of tryptophan metabolites disappear although significant
differences are observed in healthy volunteers. Some differences of age and
gender differences were shown between monopolar and bipolar depressive
patients.