Pauling, L., Itano, H.A., Singer, S.J. and Wells, I.C. (1949) Sickle Cell Anemia, a Molecular Disease. Science, 110, 543-546.
https://doi.org/10.1126/science.110.2865.543

has been cited by the following article:

• TITLE: Transcranial Doppler Ultrasonography to Prevent Cerebrovascular Accident in Children with Sickle-Cell Disease

  AUTHORS: Giuliana Carpentieri-Pipolo, Marcelo de Lima Oliveira, Fernando Mendes Paschoal Junior, Edson Bor-Seng-Shu

  KEYWORDS: Transcranial Doppler, Sickle Cell Disease, Stroke in Children, Cerebrovascular Disease

  JOURNAL NAME: Neuroscience and Medicine, Vol.10 No.2, June 10, 2019

  ABSTRACT: Sickle-cell disease (SCD) is the most common cause of ischemic stroke in children and it happens in about 11% of patients between the age of 2 and 20 years old. About 7% of the world population is affected by hemoglobin disorders, mostly sickle cell anemia. SCD has a high prevalence in the population of African offspring and it is a public health problem in Brazil that affects more than 30,000 million people. Prevention of primary stroke might be feasible with a way to identify children at greatest risk. Transcranial Doppler Ultrasonography (TCD) to SCD patients can be a valuable service that results in a significant decrease of first stroke rates. In this work, we present a review about TCD as an effective strategy to detect children with SCD who are at risk for stroke.