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has been cited by the following article:

• TITLE: Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats

  AUTHORS: Makoto Hasegawa, Junichi Hada, Tetsuya Abe, Nao Ohtsu, Kousuke Honda, Masahiro Urade

  KEYWORDS: Cyclooxygenase-2 (COX-2), Etodolac, Fear Memory, Hippocampal Blood Flow, Mean Arterial Blood Pressure, Tooth Pulp Stimulation

  JOURNAL NAME: Neuroscience and Medicine, Vol.2 No.3, September 28, 2011

  ABSTRACT: In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg); however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.