TITLE:
Evaluation of Adverse Events Following Immunization against Rotavirus Regardless of Recommended Age Restriction
AUTHORS:
Jesus Reyna-Figueroa, Irina Jeanette Bercholc-Urinowsky, Gabriela Cardoso-Yah, Ricardo Platón Vazquez-Alvarado, Dalila Ramos-López, Freya Helena Campos-Romero, Cory Handelsman, Ana Elena Limón-Rojas
KEYWORDS:
Rotavirus, Vaccination, Age Restriction, Adverse Reaction
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.8,
August
17,
2017
ABSTRACT: Introduction: Mild
and moderate Adverse Events Following Immunization (AEFI) against Rotavirus has
not received much attention when the vaccine is administered regardless of
recommended age restriction. Objectives: To describe the behavior of
mild and moderate AEFI in immunized subjects against Rotavirus, in who age
restriction period had not been considered. Methods: A case-control
study in which we included immunized patients with monovalent oral vaccine
against rotavirus and divided them into two groups: 1) Infants who received RV1
vaccine without considering the recommended period, and 2) Infants who were
vaccinated with the recommended schedule. Results: From the total doses,
143/1894 (7.5%) were administered outside the restriction period. The most
frequent AEFIs with the first dose were purpura, polypnea, and rhinorrhea; For the second dose: purpura,
bloody stools, irritability and rhinorrhea. Conclusions: This study
shows the benefits from vaccination regardless of age restriction are more
beneficial compared to the possible risks of AEFI.