TITLE:
Biochemical and Haematological Effects of the Leaf Extract of Newbouldia laevis in Alloxan-Induced Diabetic Rats
AUTHORS:
Chinyelu Clementina Osigwe, Peter Achunike Akah, Chukwuemeka Sylvester Nworu
KEYWORDS:
Haematological, Biochemical, Newbouldia laevis, Diabetes, Anti-Oxidant
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.6,
June
27,
2017
ABSTRACT: Dichloromethane-methanol
(1:1) extract (DME) of N. laevis leaves was prepared by cold maceration.
The effects of the extract on the haematological and some biochemical
parameters of alloxan-induced diabetic rats were investigated. The results
showed that the oral administration of the extract (250, 500, 1000 mg/kg)
caused a significant (P p 0.05) and dose-dependent
reduction in the platelet count and the white blood cells (WBC). The activities
of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and
alkaline phosphatase (ALP) were significantly (p 0.05) decreased. This effect was not dose
related. The serum levels of total bilirubin, urea and creatinine were
significantly (p 0.05)
decreased. The serum total protein and total antioxidant status (TAS)
significantly (p 0.05)
increased dose dependently. Overall, administration of DME has significant
ameliorative effect on alloxan-induced anaemia and other haematological alterations
in diabetes and this may be of immense benefits in the management of diabetes
and its associated haematological complications. Improved liver and kidney
functions as well as improved antioxidant status are beneficial in the
management of chronic diseases such as diabetes.