TITLE:
The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity
AUTHORS:
Anatoly I. Bozhkov, Yuriy V. Nikitchenko, Katerina N. Lebed’, Olena S. Linkevych, Natalia I. Kurguzova, Olena M. Klimova, Mohammad A. Y. Al Begai, Ali M. M. Al-Bahadly, Mohammad M. A. Alsardia
KEYWORDS:
Aging, Oxidative Stress, Cyclic Feeding Regime, Primary Immunity, Pro-Oxidant System
JOURNAL NAME:
Advances in Aging Research,
Vol.5 No.6,
November
10,
2016
ABSTRACT:
We developed an experimental model of a cyclic feeding regime (CFR) that increased a lifespan in rats. The manifestations of oxidative stress and their interrelation with parameters of cell immunity were assessed in rats at CFR. It is shown that changes of body mass, liver mass and indexes of pro/antioxidant system after periods of starving—ad libitum nutrition at CFR diet in old animals were less pronounced than in young animals. The body mass loss of 30% in 14 days was accompanied by oxidative stress. Indexes of phagocytosis did not change, but activity of oxidase system of neutrophil was increased in 2 times. The response of metabolic and physiological systems on repeat starving—ad libitum nutrition cycles differs from the response to the initial cycle of CFR. This is interpreted as a change of adaptation strategy and the effect of metabolic memory, which influences the choice of organism strategy of adaptation for subsequent starving. The dynamics of change of the studied indexes in response to CFR was age-dependent. It was supposed that different answer to CFR in young and old animals is determined by the different amount of carbon and fat depots in young and old animals.