Van Kempen-Harteveld, M.L., Brand, R., Kal, H.B., Verdonck, L., Hofman, P., Schattenberg, A., Van der Maazen, R., Corneissen, J., Eijkenboom, W., van der Lelie, J., Oldenburger, F., Barge, R., van Biezen, A., Vossen, J., Noordijk, E. and Struikmans, H. (2008) Results of Hematopoietic Stem Cell Transplantation after Treatment with Different High-Dose Total-Body Irradiation Regimens in Five Dutch Centers. Int. J. Radiation Oncology Biol. Phys., 71, 1444-1454.
http://dx.doi.org/10.1016/j.ijrobp.2007.11.072

has been cited by the following article:

• TITLE: Low Dose Total Body Irradiation (600 cGy) as a Conditioning Regimen in Allogenic Hematopoietic Stem Cell Transplant in Children with Acute Lymphoblastic Leukemia

  AUTHORS: Alberto Olaya-Vargas, Martín Pérez-García, Nideshda Ramírez-Uribe, M. Angeles Del Campo-Martinez, Gerardo Lopez-Hernández, Montserrat Hernández-García, Jorge Amador-Zarco, Guadalupe Garcia-Vega, Yadira Melchor-Vidal, Marta Zapata-Tarres, Rocío Cárdenas-Cardos, Roberto Rivera-Luna

  KEYWORDS: Total Body Irradiation, Stem Cell Transplantation

  JOURNAL NAME: Journal of Cancer Therapy, Vol.7 No.8, August 10, 2016

  ABSTRACT: Total body irradiation (TBI) is conditioning regimen in children with acute lymphoblastic leukemia (ALL) with a very high risk of relapse or in those who have not achieved remission and have relapsed and subsequently received allogenic hematopoietic stem cell transplantation (HSCT). A retrospective evaluation of 33 ALL patients in full remission with an indication of HSCT was performed to evaluate overall survival (OS) and event-free survival (EFS). The inclusion criteria included a myeloablative conditioning regimen of TBI at a dose of 600 cGy. The observed OS at 5 years was 50%, and the EFS of 32% we observed difference in the EFS stem cell origin; the peripheral blood (PB) 60%, and the umbilical cord blood (UC) accounted for 40%. Overall, 45% had a documented chimerism. The OS at 5 years from patients with chimeras was 75%, while those without chimeras had an OS at 5 years of 25%. The mortality in the first 100 days was 24%. A total of 24.2% of children presented with acute graft versus-host disease (GVHD), while 33% had chronic GVHD. Currently, there is no general agreement among all international centers regarding the optimum TBI dose. Our study reports an acceptable range of adverse events with a relatively low dose of 600 cGy.