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has been cited by the following article:

• TITLE: Formulation and Evaluation of Mucoadhesive Microspheres of Pioglitazone Hydrochloride Prepared by Ionotropic External Gelation Technique

  AUTHORS: Nagarajan Sriram, Prakash Katakam

  KEYWORDS: Diabetes Mellitus, Mucoadhesive Microspheres, Mucoadhesive Polymers, Mucoadhesion, Sustained Release, Ionotropic External Gelation Technique

  JOURNAL NAME: Journal of Encapsulation and Adsorption Sciences, Vol.6 No.1, March 15, 2016

  ABSTRACT: Microspheres containing Pioglitazone hydrochloride were prepared by the ionotropic external gelation method, using sodium alginate with four mucoadhesive polymers namely sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose, carbopol 934 P and cellulose acetate phthalate as coat materials. Ionotropic gelation is a method to prepare microspheres using combination of Ca2+ as cationic components and alginate as anion. The practical yield of prepared microspheres using the ionotropic gelation technique was between 172 mg and 604 mg. The result of the Chi-squared test carried out between the actual (practical) and expected (theoretical) yields showed no significant difference (P ex-vivo wash-off test shows the best mucoadhesive property. The in vitro drug release studies do up to 18 h. As observed from the various plots, most of the formulations followed the Korsmeyer-Peppas model.