Article citationsMore>>
Tang, Y., Xu, H., Du, X., Lit, L., Walker, W., Lu., A, Ran, R., Gregg, J.P., Reilly, M., Pancioli, A., Khoury, J.C., Sauerbeck, L.R., Carrozzella, J.A., Spilker, J., Clark, J., Wagner, K.R., Jauch, E.C., Chang, D.J., Verro, P., Broderick, J.P. and Sharp, F.R. (2006) Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. Journal of Cerebral Blood Flow & Metabolism, 26, 1089-1102. doi:10.1038/sj.jcbfm.9600264
has been cited by the following article:
-
TITLE:
Effects of genetic and environmental factors and gene-environment interaction on expression variations of genes related to stroke in rat brain
AUTHORS:
Yuan De Tan, Myriam Fornage
KEYWORDS:
Rat; Ischemia Stroke; Microarray; Differential Expression; Genotype; Environment Factor; GE- Interaction.
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.1 No.2,
July
22,
2011
ABSTRACT: To determine if genetic and environmental (dietary) factors and gene-environment interaction impact on the expression variation of genes related to stroke, we conducted microarray experiments using two homozygous rat strains SHRSR and SHRSP fed with high and low dietary salt levels. We obtained expression data of 8,779 genes and performed the ranking analysis of microarray data. The results show that the genetic difference for stroke in rat brain has a strong effect on expression variations of genes. At false discovery rate (FDR) ≤ 5%, 534 genes were found to be differentially expressed between the genotypes resistant and prone to stroke, among which 304 genes were up-regulated in the resistant genotype and down-regulated in the prone genotype and 230 were down-regulated in the former and up-regulated in the latter. In addition, 365 were functional genes for transcription and translation, receptors (in particular, neurotransmitter receptor), channels of ions, transportation, metabolism and enzymes, and functional and structural proteins. Some of these genes are pivotal genes that cause stroke. However, dietary salt levels and GE interaction do not strongly impact on the expression variations of these genes detected on arrays.
Related Articles:
-
Peter Ondruš, Roman Alberty, Timothy Lyons, Stephen Muza, Vincent Echavé, Jacques Poisson, Allen Cymerman
-
Jiang Wu, Ping Liu, Jie Lei, Jia Liu, Hong-Liang Zhang
-
Saya Natsui, Megumi Sato, Tomomi Yokoyama, Hiromi Inaba, Naomi Kuboyama, Kenichi Shibuya
-
P. Pifarré, G. Cuberas, B. Benejam, L. Frascherri, J. Sahuquillo, J. Castell-Conesa
-
Mark W. Davies, Kimble R. Dunster, John F. Fraser, Paul B. Colditz