TITLE:
BCG Infection after Bladder Cancer Treatment—3 Clinical Case Reports
AUTHORS:
Joana Alves, Angélica Ramos, Teresa Carvalho, Susana Silva, João Tiago Guimarães, António Sarmento
KEYWORDS:
Bacillus Calmette-Guérin, Intravesical BCG Therapy, BCG Infection, Disseminated M. bovis BCG Infection
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.4,
December
25,
2015
ABSTRACT: Immunotherapy with
Bacillus Calmette-Guérin (BCG) to treat non-muscle invasive bladder cancer has
become an effective and superior alternative to chemotherapy. Intravesical
treatment with BCG appears to be relatively safe; however, occasionally BCG
infection complicates such treatment. In the present work we describe three
patients in whom BCG infection occurred after intravesical BCG therapy. All
patients had positive urine culture forMycobacterium tuberculosis complex, using AccuProbe culture
identification and then Genotype Mycobacterium MTBC test identified Mycobacterium bovis BCG. The diagnosis is difficult
and microbiologic study is usually negative, so high index of suspicion is
essential.