TITLE:
Granulosa Cell Tumors of the Ovary: Retrospective Analysis of 17 Cases
AUTHORS:
Hala Aziz Shokralla, Ahmed Elsayed Fathalla
KEYWORDS:
Granulosa Cell Tumors, Ovary, Outcomes
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.11,
October
30,
2015
ABSTRACT: Background: Granulosa cell tumors (GCTs) are rare neoplasms with a relatively
favorable prognosis. They are characterized by a prolonged history and a tendency
to late recurrences. It is the most common type of sex cord-stromal tumors. Aims:
To analyze, to report and to better understand the clinico-pathologic features and
results of treatment, and prognostic factors of these tumors. Materials and Methods:
A retrospective single-institutional review 17 cases of GCTs were treated in National
Cancer Institute—Cairo University from January 2010 till December 2014. The clinical
and pathological characteristics, treatment, and outcomes of patients with ovarian
GCTs were analyzed. Results: Data from 17 patients were obtained. The median age was 54 years (range; 14 - 72). Abdominal
pain was the most common presentation (64.7%). The mean tumor size was 14 cm (range;
7 - 23 cm). The majority of our patients were stage I (n = 11; 64.7%), while (n
= 3; 17.6%) had stage III and (n = 2, 11.8%) were stage IV. Only one case (5.9%)
had an unknown stage (explored outside NCI). The majority of cases were of adult
type disease (n = 14) and low grade pathology (n = 10). In follow-up period (median
= 42 months; ranging 9 - 60) three patients relapsed; the median overall survival
time was not reached yet, however, the estimated 3-year survival was 72.5%. Conclusion:
Granulosa cell tumors are rare neoplasms of the ovaries. They progress slowly and
often are diagnosed in an early stage. Surgery is the main line of treatment. Prolonged
post-therapeutic follow-up is necessary. Definition of proper prognostic factors
is mandatory.