TITLE:
Effects of Aerobic Exercise on the Intramuscular Lipid and Glycogen Content of Fiber Types in Soleus Muscles of Non-Alcoholic Steatohepatitis Model Rats
AUTHORS:
Miyako Mochizuki, Emi Hayashi, Atsushi Yoshimura, Yuko Toyoda, Lin Mei, Noboru Hasegawa
KEYWORDS:
Metabolic Disease, Non-Alcoholic Steatohepatitis, Intramuscular Lipid, Triglyceride, Glycogen, Histopathological, Fiber Types, Aerobic Exercise
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.10,
October
22,
2015
ABSTRACT: We studied the effects of
exercise on muscle mitochondria, and lipid and glycogen content in non-alcoholic
steatohepatitis (NASH) model rats. Male Sprague-Dawley rats were randomly
separated into 3 groups: the control group was fed standard chow; the NASH
group was fed a methionine-choline-deficient high-fat diet (MCD); the
NASH-exercise group was fed the MCD and exercised three times a week. Exercise
training consisted of continuous running for thirty minutes at a 13 m/min, 6° slope on a motor-driven rodent treadmill for 6 weeks. Mitochondria content in
NASH group decreased in the both fiber types compared with those of the control
group. As compared between the NASH and NASH-exercise groups, however, exercise
not only promoted significant improvements in liver fibrosis and cirrhosis and
triglyceride (TG) content but also increased mitochondria content in type I
muscle fiber in particular. These data suggest that exercise improved hepatic
steatosis in NASH model rats and can prevent the progression of NASH.