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http://dx.doi.org/10.1124/jpet.105.092684

has been cited by the following article:

• TITLE: Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug

  AUTHORS: Bassam Saif, Congli Wang, Dong Chuan, Shaomin Shuang

  KEYWORDS: Magnetic Nanoparticles, Drug Delivery, Flavonoid, Morin

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.6 No.4, October 21, 2015

  ABSTRACT: Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.