TITLE:
Analysis on Immune Tolerance and Resistance Mechanism of Cryptococcus albidus of AIDS Patients with Opportunistic Cryptococci Infection
AUTHORS:
Xiaobing Yang, Guosheng Su, Lida Mo
KEYWORDS:
AIDS Patients, Opportunistic Infections, Cryptococcus albidus, Analysis of Drug Resistance
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.3,
September
29,
2015
ABSTRACT: Objective: To explore more
about the immune tolerance and drug resistance of white Cryptococci
albidus in
AIDS patients with opportunistic Cryptococcus infection.
Methods: To analyze drug resistance of the samples of white Cryptococcus
albidus extracted from
opportunistic infection AIDS patients in the certain infection area from
October 2011 to December 2014. Results: After analyzing two samples of Cryptococcus albidus from 885 cases with opportunistic
infection, we found that one of the samples do resist to ten common
antibiotics. They were fluconazole, flu-cytosine, fluconazole, caspofungin,
amphotericin B, MI miconazole, terbinafine, ketoconazole and itraconazole. The
other one was sensitive to voriconazole, but resistant to the rest of the drug.
Two strains of bacteria were inoculated into the animals in vivo and their DNA was extracted to carry
out the genotyping analysis. The results showed that different degrees of
resistance gene amplification bands were found in the 10 kinds of antibiotics.
Conclusion: Although there were few opportunistic infection Cryptococcus albidus in AIDS patients, it was easy to show
its resistance to drugs. Therefore, great attention should be paid to it for
the medical workers.