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has been cited by the following article:

• TITLE: Iron Depletion Improves Glycemic Control in Poorly Controlled Type 2 Diabetic Patients with Iron Overload and Negative Main HFE-Gene Mutations

  AUTHORS: Adel A. Mahmoud, Adel A. Elazab Elged, Rasha A. Elgamal, Abdelhady M. Hamada

  KEYWORDS: Iron Overload, Poorly Controlled Diabetes, Phlebotomy, Hypertension, Dyslipidemia

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.5 No.3, July 29, 2015

  ABSTRACT: Iron overload increases the risk of diabetes via mechanisms of abnormal glucose metabolism: insulin deficiency, insulin resistance, and/or hepatic dysfunction. Iron reduction upregulates glucose uptake and improves hepatocytes insulin receptor activity. This study was conducted to examine the effects of iron depletion—via controlled phlebotomy—on the hypoglycemic treatment in poorly controlled type 2 diabetes mellitus (T2DM) patients with non-genetic iron overload. Forty three patients with poorly controlled T2DM and iron overload were divided into 2 groups: iron depletion group and control group. Regular phlebotomy was performed for iron depletion group on monthly basis until serum ferritin reached 20 μg/L or less. Both groups were examined and compared for blood pressure, serum ferritin, lipid profile, HFE-gene, HbA1c, HOMA-IR and number of medicines used for diabetic control. The results had revealed that group differences of HbA1c (-2.64, 95% CI -3.23 to 2.04, p -0.68, 95% CI -0.98 to -0.37, p