TITLE:
Indoor Particulate Matter Associated with Systemic Inflammation in COPD
AUTHORS:
S. Bose, N. N. Hansel, E. S. Tonorezos, D. L. Williams, A. Bilderback, P. N. Breysse, G. B. Diette, Meredith C. McCormack
KEYWORDS:
Particulate Matter, Indoor Pollution, Chronic Obstructive Pulmonary Disease (COPD)
JOURNAL NAME:
Journal of Environmental Protection,
Vol.6 No.5,
May
28,
2015
ABSTRACT: Chronic obstructive
pulmonary disease (COPD) is a chronic disease characterized by progressive
airflow obstruction, along with pulmonary and systemic inflammation. Outdoor PM
has been associated with morbidity and mortality in COPD but less is known
about effects of indoor air quality. In former smokers with COPD, we
investigated in-home PM effects on pulmonary and systemic inflammation,
symptoms, and lung function. Participants underwent in-home air monitoring for
two weeks and simultaneous health assessments. Median (IQR) PM2.5 was 9 (7) μg/m3. Increased indoor PM2.5 was associated
with increased white blood cells, predominantly neutrophils and lymphocytes,
suggesting that even relatively low indoor PM2.5 may elicit a
systemic inflammatory response in COPD.