TITLE:
Inherited Thrombophilia and Early Recurrent Pregnancy Loss among Egyptian Women
AUTHORS:
Omneya M. Osman, Nelly N. Abulata
KEYWORDS:
Thrombophilia, Recurrent Pregnancy Loss, Genetic Mutations, MTHFR
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.5,
May
8,
2015
ABSTRACT:
Inherited thrombophilia has been implicated as a possible cause of
recurrent pregnancy loss. Although numerous studies are available in
literature, thrombophilia rate seems to vary fromstudy to another. The aim of
our study was to determine the frequency of FII Prothrombin(G20210A), Factor V
Leiden (G1691A), as well as methyl tetrahydrofolate reductase
(MTHFRC677T) polymorphisms, protein C, protein S and antithrombin III deficiency
in a series of patients with unexplained RPL compared to control. Patients and
Methods: 100 patients of unexplained RPL and 43 age-matched healthy controls
were investigated for inherited thrombophilia. Results: MTHFR and Factor V
Leiden were the commonest gene defects among cases studied (63%, 60%
respectively) and control groups (41.9%, 41.9% respectively) (p = 0.019, p =
0.046 respectively). The least common deficiencies were protein S and protein C
deficiency in cases (3%, 2% respectively) as well as in controls (1%, 0%
respectively). 4 cases were homozygous for MTHFR and 2 cases homozygous for
Factor V Leiden mutation. Odds ratio for MTHFR and Factor V mutation was 2.36
and 2.08 respectively (CI 95%). Combined defects were seen in cases and controls
(p