TITLE:
Correlation Analysis between Mean Corpuscular Hemoglobin and Mean Corpuscular Volume for Thalassemia Screening in Large Population
AUTHORS:
Xiaoli Long, Junyu Fang, Lijun Yao, Qingqing Xiao, Tao Pan
KEYWORDS:
Thalassemia Screening, Large Population, Mean Corpuscular Hemoglobin, Mean Corpuscular Volume, Correlation Analysis
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.5 No.14,
September
30,
2014
ABSTRACT: Correlation
analysis between the hematological parameters mean corpuscular hemoglobin (MCH)
and mean corpuscular volume (MCV) for thalassemia screening in large population
was discussed. A total of 4920 peripheral blood samples of reproductive age persons
were collected from Guangdong province of China. The hematological parameters
MCH and MCV values of samples were first measured, and then the DNA analyses
for thalassemia were conducted. All samples were composed by 4463
non-thalassemia and 457 thalassemia, and among 457 thalassemia samples, 311
were α-thalassemia, 133 were β-thalassemia, and 13 were α & β-thalassemia. In accordance with non-thalassemia,
thalassemia, α-thalassemia, β-thalassemia, α & β-thalassemia and
the entire group itself, a total of six sample groups were divided. The
corresponding correlation coefficients between the measured MCH and MCV values
for the six sample groups were 0.880, 0.968, 0.966, 0.962, 0.980 and 0.965 respectively.
For the thalassemia carriers, highly significant correlation between MCH and
MCV were observed. The fitting equations between MCH and MCV values were also
obtained. The results indicated that the feasibility for thalassemia screening
using MCV or MCH independently as parameter, and provided suitable strategy to
select parameters and models for thalassemia screening in large population.