Winkler, C., Frick, B., Schroecksnadel, K., Schennach, H. and Fuchs, D. (2006) Food Preservatives Sodium Sulfite and Sorbic Acid Suppress Mitogen-Stimulated Peripheral Blood Mononuclear Cells. Food and Chemical Toxicology, 44, 2003-2007.
http://dx.doi.org/10.1016/j.fct.2006.06.019

has been cited by the following article:

• TITLE: Nitric Oxide: Probably the in Vivo Mediator of the Bisulfite’s Effects

  AUTHORS: Loris Grossi

  KEYWORDS: Nitrite, Sulfite, Nitric Oxide, Antioxidant, EPR Spectroscopy

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.2 No.7, September 5, 2014

  ABSTRACT: The use of bisulfite in food and beverage preservation, as well as in commercial goods and pharmaceuticals as antimicrobial agents is well known, but not very much is reported on its action in vivo. It has been stressed that its action is connected to the presence of NO, and the only reported/ hypothesized evidence concerns the possible interaction with GSNO (S-nitrosoglutathione), an NO releaser. In this light, we investigated the interaction between GSNO and the bisulfite in an aqueous medium at pH = 6.4; actually, a positive effect of the sulfite was evidenced. i.e., the S-nitrosoglutathione becomes a more efficient NO-releaser. But, the nitrite is the real pool of NO in vivo, therefore we investigate its interaction with the bisulfite in an aqueous acidic solution at pH = 6.4; this time, a definitely efficient and abundant NO release, 3.61 times higher compared to the GSNO, has been evidenced. Therefore, these results allow hypothesizing a fundamental role of NO in the bisulfite’s action in vivo, or most probably the bisulfite acts simply as cofactor of NO-releasers.