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has been cited by the following article:

• TITLE: Osteoclast Response to Bioactive Surface Modification of Hydroxyapatite

  AUTHORS: Yohei Okazaki, Yasuhiko Abe, Keisuke Yasuda, Kyou Hiasa, Isao Hirata

  KEYWORDS: Hydroxyapatite, Phosphoric Acid, Ca/P Ratio, Osteoclast

  JOURNAL NAME: Open Journal of Stomatology, Vol.4 No.7, July 30, 2014

  ABSTRACT: The aim of this study was to evaluate the in vitro response of osteoclast-like cells (RAW 264.7 cells) to a bioactive hydroxyapatite (HAP) surface that was modified using the 30% phosphoric ac-id-etching procedure reported in our previous paper (2013). The cells on the bioactive HAP surface were multinucleated and were larger than those on the untreated HAP surface. The cell occupancies were greater on the bioactive HAP surface than on the untreated HAP surface at 7, 14, 21, and 28 days of differentiation; in particular, the values at 21 and 28 days were significantly larger (P