TITLE:
Feasibility of Outpatient Chemotherapy with S-1 and Cisplatin for Gastric Cancer
AUTHORS:
Hironaga Satake, Akihito Tsuji, Takeshi Kotake, Mikio Fujita
KEYWORDS:
Gastric Cancer, Cisplatin, S-1, Short Hydration, Outpatient Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.8,
July
7,
2014
ABSTRACT:
Objective: To evaluate the
feasibility of S-1 and high-dose cisplatin short hydration regimens for
outpatients with unresectable metastatic gastric cancer. Methods: Data for
individual outpatients treated in our institution were retrospectively pooled
to assess the feasibility of an S-1 and highdose cisplatin short hydration
regimen (S-1: 80 to 120 mg on Days 1 to 21; cisplatin: 60 mg/m2on Day 8, every 5 weeks), which
included 2250 ml of intravenous fluids and 1000 ml oral hydration. Ten
consecutive patients were treated with S-1 and high-dose cisplatin short
hydration for unresectable metastatic gastric cancer from July 2011 to May 2012
and were included in the analysis. Results: With a median of 3.5 medication
cycles, unscheduled admission occurred in two patients for 5 days each due to
paralytic ileus and cerebral infarction. Four patients required dose reduction,
in both S-1 and cisplatin in two patients, and in S-1 alone and cisplatin alone
in one patient each. Renal function transiently declined after administration
of cisplatin, but serum creatinine level and estimated glomerular filtration
rate were both improved by the time of the next administration. Conclusion:
This study suggests that an S-1 and high-dose cisplatin short hydration strategy
for outpatients with unresectable metastatic gastric cancer might be feasible.