TITLE:
Effects of hot-water extract of Paecilomyces hepiali on hypertension parameters in Spontaneously Hypertensive Rats
AUTHORS:
Alfred Chioza, Shoji Ohga
KEYWORDS:
Hot-Water Extract, Paecilomyces hepiali, Ophiocordyceps sinensis, Spontaneously Hypertensive Rats
JOURNAL NAME:
Advances in Microbiology,
Vol.4 No.8,
June
17,
2014
ABSTRACT:
In this study, effects of hot water extract
of Paecilomyces hepiali mycelia on
hypertension parameters in spontaneously hypertensive rats (SHR) were
investigated. The tested parameters included blood pressure, blood and urine
biochemical composition, renin and angiotensin II levels in the blood. Prior to
these tests, the extract was examined for toxicity. The fungus was cultivated
in a solid medium composed of 40 g brown rice, 0.32 g glucose, 0.65 g sucrose,
2 g peptone and 65 ml corn steep liquor. No abnormality or harmful effects were
observed in the toxicity test. Administration of a continuous-dose, once daily,
to SHR for 27 weeks (from 13 weeks of age) decreased the systolic blood
pressure (SBP) significantly. Levels of blood urea nitrogen, β-lipoprotein lipid peroxides and low
density lipoprotein were significantly lower in the treated groups when compared to the control group. Urinary
protein was significantly reduced in the middle and high dose groups. In comparison
with the control group (0 mg/kg/10ml/day), significantly higher values were
obtained for total cholesterol in groups that were given middle (170
mg/kg/10ml/day) and high (250 mg/kg/10ml/day) dosages. In all dosages (low,
middle and high) the values for triglyceride were significantly higher than
value found in the control group. In terms of angiotensin II levels, the value
in the control group was markedly higher than values in the other groups. The results
suggest that oral administration of hot water extract of P. hepiali mycelia has ability to control hypertension in rats.