TITLE:
Production of Citric Acid from Corncobs with Its Biological Evaluation
AUTHORS:
Ahmed Ashour, Saleh El-Sharkawy, Mohamed Amer, Amani Marzouk, Ahmed Zaki, Asuka Kishikawa, Momiji Ohzono, Ryuichiro Kondo, Kuniyoshi Shimizu
KEYWORDS:
Corncobs, Citric Acid, Fermentation, Melanin, Allergy, Hyaluronic Acid
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.3,
May
22,
2014
ABSTRACT:
Corncobs could serve as a
substrate for citric acid production using solid state fermentation technique.
The culture optimization concerning substrate concentration, culture duration,
pH, temperature and substrate hydrolysis was carried out for maximum
productivity of citric acid. Under the optimized conditions, 48.4 g of citric
acid was produced from 1 kg dry corncobs. Biological evaluation was carried out
for citric acid such as melanin synthesis inhibitory, anti-allergy, anti-bacterial,
and hyaluronic acid production activities. The results showed that citric acid
has potent melanin inhibitory activity, good inhibition for β-hexosaminidase release and
potent stimulatory effect for the production of hyaluronic acid. These
activities (melanin synthesis inhibitory, anti-allergy and hyaluronic acid
productive activities) of citric acid have been reported for the first time.