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Shen-Orr, S.S., Goldberger, O., Garten, Y., Rosenberg-Hasson, Y., Lovelace, P.A., Hirschberg, D.L., Altman, R.B., Davis, M.M. and Butte, A.J. (2009) Towards a Cytokine-Cell Interaction Knowledgebase of the Adaptive Immune System. Pacific Symposium on Biocomputing, 2009, 439-450.
has been cited by the following article:
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TITLE:
Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer
AUTHORS:
Adi Prayitno, Okid Parama Astirin, Suhartono Taat Putra
KEYWORDS:
IL-2, IL-10, Immune Response, Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.5,
April
23,
2014
ABSTRACT:
Introduction:
Interleukin-2 (IL-2) is multiple which functions during an inflammatory
response. Inflammation is a critical component of cancer progression. IL-10 is
the most important cytokine with anti-inflammatory properties. Cancer patients
typically show depression of both cellular and humoral immune functions. Aims:
The objective of this experiment is to know the expression of IL-2 and IL-10 in
cervical cancer. Method: Paraffin block of the tissues frozen section cervical
cancer was cut in sharp and cleaned cryotome and place in glass plate that
covered with poly-elysine. The immunohistochemistry stains were done with
monoclonal antibody anti IL-2 and IL-10 with TSA-indirect method. The collected data were
analyzed with T Test (SPSS for window 15). Result: In this study the expression
of IL-2 (35.9% = moderate) is less than the expression of IL-10 (45.3% =
moderate). From T Test analysis of p
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