TITLE:
Serum Transferrin Receptors in Children with Hypochromic Microcytic Anaemia
AUTHORS:
Maria Aslam, Shahida Mohsin, Huma Amin, Shabbir Hussain, Nisar Ahmed, Ayesha Bhalli
KEYWORDS:
Iron Deficiency Anaemia (IDA), Anaemia of Chronic Disorders (ACD), Serum Transferrin Receptors (sTfR)
JOURNAL NAME:
Open Journal of Pathology,
Vol.4 No.2,
April
22,
2014
ABSTRACT:
Hypochromic
microcytic anaemia includes iron deficiency, anaemia of chronic disorders, beta
thalassemia trait and sideroblastic anaemia. To rule out the cause of
hypochromic microcytic anaemia is a diagnostic difficulty. The conventional
laboratory tests used for diagnosis have few disadvantages. Serum transferrin
receptor (sTfR) is the most reliable method for assessment of body iron. Eighty
four children were included in this study. They were further divided into four groups:
iron deficiency anaemia (IDA), anaemia of chronic disorders (ACD), beta thalassemia trait (β TT) and controls. Children withIDAand ACD were diagnosed
on the basis of history and serum iron profile. Subjects with β TT had HbA2 > 3.5%. sTfR were performed on all subjects. Level of
sTfR in patients withIDAwas 5.79 μg/ml ± 1.3 μg/ml. In
patients with anaemia of chronic disorders (ACD), β thalassemia trait and controls mean sTfR were 2.18 μg/ml ± 0.6 μg/ml,
2.1μg/ml ± 0.5 μg/ml and 2.0 μg/ml ± 0.5 μg/ml respectively. These results show level of sTfR was raised in IDA
when compared with controls or ACD and β TT (p value