TITLE:
ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone
AUTHORS:
Nicholas Greco, Trevor Schott, Xiaodong Mu, Adam Rothenberg, Clifford Voigt, Richard L. McGough III, Mark Goodman, Johnny Huard, Kurt R. Weiss
KEYWORDS:
Osteosarcoma, Chondrosarcoma, Ewings Sarcoma, Aldehyde Dehydrogenase, Metastases
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.4,
March
31,
2014
ABSTRACT:
Osteosarcoma (OS),
chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary
malignancies of bone, and are rare diseases. As with all sarcomas, the
prognosis of these diseases ultimately depends on the presence of metastatic
disease. Survival is therefore closely linked with the biology and metastatic
potential of a particular bone tumor’s cells. Here we describe a significant
correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence
of distant metastases in ten consecutive cases of human bone sarcomas. Additionally,
cultured human CSA cells, which are historically chemo- and radio-resistant,
may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to
draw broad conclusions from such a small series, the importance of ALDH
activity and inhibition in the metastatic potential of primary bone sarcomas
should be investigated further.