Article citationsMore>>
Gridelli, C., Perrone, F., Gallo, C., Cigolari, S., Rossi, A., Piantedosi, F., Barbera, S., Ferraù, F., Piazza, E., Rosetti, F., Clerici, M., Bertetto, O., Robbiati, S. F., Frontini, L., Sacco, C., Castiglione, F., Favaretto, A., Novello, S., Migliorino, M.R., Gasparini, G., Galetta, D., Iaffaioli, R.V. and Gebbia, V. (2003) MILES Investigators. Chemotherapy for Elderly Patients with Advanced Non-Small-Cell Lung Cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) Phase III Randomized Trial. Journal of National Cancer Institute, 95, 362-372.
http://dx.doi.org/10.1093/jnci/95.5.362
has been cited by the following article:
-
TITLE:
Chemotherapy (Gemcitabine plus Carboplatin versus Paclitaxel plus Carboplatin) in Elderly Patients with Non-Small Cell Lung Cancer
AUTHORS:
Takanori Ayabe, Masaki Tomita, Eiichi Chosa, Makoto Ikenoue, Yukie Shirasaki, Kunihide Nakamura
KEYWORDS:
Elderly; Lung Cancer; Chemotherapy; Paclitaxel; Gemcitabine; Carboplatin
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.3,
March
25,
2014
ABSTRACT:
Background: This retrospective study was to evaluate the efficacy and toxicity of gemcitabine plus carboplatin (GC regimen) and paclitaxel plus carboplatin (PC regimen) combination chemotherapy in elderly patients with non-small cell lung cancer. Methods: Seventy-four patients (GC regimen, n = 44; PC regimen, n= 30) received gemcitabine at a dose of 1000 mg/m2 on days 1 and 8, and carboplatin with the target dose of area under the curve (AUC) of 4 on day 8 every 28 days and paclitaxel at a dose of 70 mg/m2 on days 1, 8 and 15, and carboplatin with the target dose of AUC of 5 on day 1 every 28 days. Patients were divided in two groups (younger one: n = 42, old; elderly one: n= 32, ≥70 years old). Results: A total of 222 cycles of the treatment wasadministered. Seventy-one patients (95.9%) completed the scheduled cycles. Two patients in the elderly group were discontinued (6.3%) due to hematological toxicity and melena in the GC regimen and to grade 4 pneumonia in the PC regimen. The dose was reduced in 8 patients (10.8%) due to grade 4 thrombocytopenia. Grade 3/4 neutropenia was not significantly observed in both groups (younger group: 24/42, 57.1%; elderly group: 19/32, 59.4%, p = 0.8471). The nonhematological toxicities were mild in both groups. However, in theelderly group, grade 3/4 thrombocytopenia was significantly observed in the GC group (GC: 5/17, 29.4%; PC: 0/15, 0.0%, p = 0.0222). There was no treatment-related death. Conclusion: These results demonstrate that the GC and PC combination chemotherapies are efficacious and feasible regimens for lung cancer therapy, especially, both regimens should be considered as one of the standard therapies for elderly patients during lung cancer therapy.
Related Articles:
-
Takanori Ayabe, Masaki Tomita, Eiichi Chosa, Makoto Ikenoue, Yukie Shirasaki, Kunihide Nakamura
-
Ghada Ezzat Eladawei, Rasha Mohamed Abdellatif, Sheref Mohamed El-Taher
-
Hala Aziz Shokralla, Mohamed Rahouma
-
Md Rejaul Hoq, Mohammad R. Karim, Md. Arifuzzaman, Aminul H. Mirza
-
Md. Razzak, Mohammad R. Karim, Md. Rejaul Hoq, Aminul H. Mirza