TITLE:
Clinical Profile and Treatment Management of Heart Failure with Preserved Systolic Function in Rural Setting of India
AUTHORS:
Tom Devasia, Sunil Datta Nandibandi, Rama Bhat, Hashir Kareem, Ashok Thakkar
KEYWORDS:
Diastolic Heart Failure; Epidemiology; Heart Failure; Normal Ejection Fraction
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.5,
March
14,
2014
ABSTRACT:
Background: In recent decades, the hospital admission
due to heart failure with normal ejection fraction (HFnEF) or diastolic heart
failure has increased particularly in elderly patients. However, sufficient
data regarding prevalence, etiologies and treatment of diastolic heart failure
are not available for Indian population. So, we carried out an observational study to determine clinical profile and
medical therapy for patients experiencing diastolic heart failure.
Methods: This was prospective observational study carried out in rural area of
India for the period of 12 months. All the patients diagnosed with heart
failure with normal ejection fraction were included in the study. If the
patient was having severe anemia (hemoglobin 8.00 g/dl), hemodynamically significant valvular
disease, prosthetic valve replacement, and ventricular pacemaker, they were excluded. Results: A
total of 53 patients diagnosed with HFnEF were included in the study. There
were 24 male patients. Hypertension, CAD and diabetes mellitus were present in 33, 24 and 16
patients respectively. 18 patients developed severe diastolic dysfunction and
more common in female as compared to male (37.9% vs. 33.3%). Most frequently
observed clinical feature was tachycardia (96% cases) followed by pedal edema
(86%). The patients were treated according to underlying cause. Conclusions:
Diastolic heart failure is more common in elderly patients. In Indian population,
diastolic heart failure has been associated with hypertension, diabetes
mellitus and coronary artery diseases in most of the cases.