TITLE:
Association of four GSTs gene polymorphisms with Parkinson disease: A meta-analysis
AUTHORS:
Dongjun Dai, Yunliang Wang, Lingyan Wang, Jinfeng Li, Hanlin Zhou, Qingqing Ma, Xingyu Zhou, Jun Pan, Guanghui Pan, Cheng Chen, Limin Xu, Ping Ru, Hui Wang, Shengqian Zhu, Yuelong Lv, Leiting Xu, Meng Ye, Shiwei Duan
KEYWORDS:
Parkinson; GSTM1 Deletion Polymorphism; Meta-Analysis; Europeans; GSTT1; GSTP1
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.2,
January
24,
2014
ABSTRACT:
Parkinson disease (PD) is a neurological disorder
with huge destruction to human body, which affects approximately 2% of the
population aged 65 years or older. As antioxidants in the stress defence
systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with
an important role in the pathogenesis of PD. The aim of this study was to
evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses
were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls
between four polymorphisms (GSTT1
deletion polymorphism; GSTM1
deletion polymorphism; GSTP1-104:
rs1695; GSTP1-114: rs1799811) and PD.
There is no significant association between the four GST gene variants and PD.
A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in
Europeans (p = 0.013, OR = 1.126, 95%
CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975).
Our meta-analysis suggested that GSTM1 deletion polymorphism increased the
risk of PD in Europeans, but reduced the risk of PD in Latin Americans.
Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association
of PD for other GST genetic polymorphisms.