TITLE:
Family and/or Friends? Gene Mapping at Crossroads
AUTHORS:
Muhammad Sajjad, Sultan Habibullah Khan, Rashid Mehmood Rana
KEYWORDS:
Family Based Mapping; LD Mapping; NAM
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.5 No.1,
January
14,
2014
ABSTRACT:
Mapping gene(s) underlying a specific trait offers
an opportunity to plant breeders to apply marker assisted selection. All gene mapping approaches except LD mapping use family based segregation
populations developed by crossing two or more parents. These family based gene
mapping approaches include simple
interval mapping, composite interval mapping, multiple interval mapping and Bayesian mapping etc. Each approach has its own
advantages and disadvantages based on type of population and underlying
statistical model. Unlike family based approaches, LD mapping uses population
of unrelated individuals which are like friends belonging to different family
backgrounds. Relative pros and cons of family and
friends based approaches make them complementary
to each other. Family based approaches identify wide chromosomal region
underlying the trait of interest with relatively lower markers density, and therefore, have low mapping resolution. Conversely, friends
based LD mapping identifies
chromosomal region of interest with higher resolution using higher marker
density. The integration of family and friends based approaches addresses their
respective pros and cons successfully to enhance mapping resolution for more
valid application of marker assisted selection.