TITLE:
Iatrogenic calcinosis cutis in a child affected by Acute Lymphoblastic Leukemia
AUTHORS:
Teresa Perillo, Giampaolo Arcamone, Domenico Bonamonte, Michele Pascone, Nicola Santoro
KEYWORDS:
Calcinosis Cutis; Treatment; Immunocompromised; Leukemia
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.1,
January
13,
2014
ABSTRACT:
Iatrogenic
calcinosis cutis is a
rare disorder that can be due to the intravenous administration of calcium or
phosphate-containing infusions such as calcium gluconate or calcium chloride
with extravasation. Fortunately, the course of calcinosis cutis is benign in
immunocompetent children. The treatment remains
supportive therapy. After about 6 months, there is no evidence of tissue
calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia
(ALL) who developed severe calcinosis cutis in the left humerus after
extravasation of calcium gluconate during the treatment for the tumor-lysissyndrome-related
hypocalcaemia. Surgical debridement and local wound care were not successful, and so a temporary suspension of chemotherapy was necessary to achieve complete healing
of the lesion. Notwithstanding this complication, her ALL is in complete
hematological remission after 8 months from the diagnosis. No functional or
sensitive impairment due to the cutis has persisted.