Article citationsMore>>
Cesaro, S., Hirsch, H.H., Faraci, M., Owoc-Lempach, J., Beltrame, A., Tendas, A., Baltadakis, I., Dalle, J.H., Koc, Y., Toporski, J., Styczynski, J., Yesilipek, M.A., Heinz, W., Caniglia, M., Rascon, J., Fauser, A.A., Michallet, M., Lopez-Corral, L., Neuburger, S., Tridello, G. and Einsele, H. (2009) Cidofovir for BK virus-associated hemorrhagic cystitis: A retrospective study. Clinical Infectious Diseases, 49, 233-240. doi:10.1086/599829
has been cited by the following article:
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TITLE:
Cyclophosphamide induces an early wave of acrolein-independent apoptosis in the urothelium
AUTHORS:
Francis M. Hughes, Alexa G. Corn, Andrew R. Nimmich, Jeffery D. Pratt-Thomas, J. Todd Purves
KEYWORDS:
Cystitis; Cyclophosphamide; Apoptosis; Bladder; Urothelium
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.8B,
August
8,
2013
ABSTRACT:
Hemorrhagic cystitis (HC) affects a significant number of patients undergoing cyclophosphamide (CP) chemotherapy despite treatment
with 2-mercaptoethane sulfonate
(Mesna) to inactivate the metabolite acrolein. While the mechanism is unknown,
there is clearly acrolein-independent damage to the urothelium. In this study
we have explored the induction of apoptosis in the urothelium as a marker of
damage and the mechanism underlying the acrolein-independent apoptosis. Two
waves of apoptosis (measured as caspase-3/7 activity and Poly (ADP-ribosyl) polymerase (PARP) cleavage) were detected following CP administration, one peaking
at 2 h and a second at 48 h. The first wave was not blocked by Mesna, indicating
it was independent of acrolein. Caspase-1 was also active at 2 h and activation
of caspase-3/7 was blocked by a caspase-1 inhibitor, but not an IL-1 receptor
antagonist, suggesting the direct activation of caspase-3/7 by caspase-1
without the need for IL-1 as an intermediate. Our results indicate that CP
initiates an early, acrolein-independent wave of apoptosis that results from
direct cleavage of caspase-3/7 by caspase-1.
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