W. Jaffe and D. Scott, “Total Hip Arthroplasty with Hydroxyapatite-Coated Prosthesis,” Journal of Bone and Joint Surgery, Vol. 78, No. 12, 1996, pp. 1918-1934.

has been cited by the following article:

• TITLE: The Effect of Si-Doping on the Release of Antibiotic from Hydroxyapatite Coatings

  AUTHORS: Mirjam Lilja, Carl Lindahl, Wei Xia, Håkan Engqvist, Maria Strømme

  KEYWORDS: Titanium Dioxide; Hydroxyapatite; Cephalothin; Drug Release; Si-Doping

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.4 No.3, June 26, 2013

  ABSTRACT: Herein, we show that incorporation of ions during biomimetic coating deposition may be utilized to tailor the drug loading capacity of hydroxyapatite (HA) coatings. Pure biomimetic HA (HA-B) and Si-doped equivalents (SiHA-B) where deposited by a biomimetic process onto titanium dioxide covered titanium substrates. The antibiotic Cephalothin was incorporated into the coatings by adsorptive loading and the release was studied in-vitro. SiHA-B coatings exhibited superior drug incorporation capacity compared to pure HA-B coatings, resulting in a drug release profile dominated by an initial 10 min burst effect while a more prolonged 10 hour release was observed from HA-B coatings. The results emphasize the possibility to impact the drug release kinetics from implant coatings by selective doping elements and the use of thin, biomimetic HA-coatings as drug delivery vehicles. Functionalizing metal implants with SiHA-B coatings presents an interesting strategy towards creating synergetic effects through ion- and antibiotic release and, hence, contributing both towards preventing post-surgical infections while at the same time enhancing the bone-bonding ability.