TITLE:
Development of Film Dosage Forms Containing Miconazole for the Treatment of Oral Candidiasis
AUTHORS:
Yoshifumi Murata, Takashi Isobe, Kyoko Kofuji, Norihisa Nishida, Ryosei Kamaguchi
KEYWORDS:
Film Dosage Form; Miconazole; Oral Candidiasis; Natural Polysaccharide; Surface Active Agent
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.4 No.3,
June
20,
2013
ABSTRACT:
Film dosage forms (FDs) containing miconazole (MCZ) for the treatment
of oral candidiasis were prepared using water-soluble polysaccharides, and the dissolution profiles of MCZ from
the FDs were investigated. In addition, the forms were modified by the addition
of a surface active agent to accelerate the drug dissolution rate. Circular
films incorporating MCZ were obtained using each polysaccharide. Most FDs were easy
to handle and resistant to tearing. No diffraction peaks were observed in the X-ray diffractograms of FDs. FDs
prepared with sodium alginate or pullulan immediately swelled and disintegrated in aqueous medium, whereas MCZ
incorporated in the FD gradually dissolved. A marked acceleration in the MCZ dissolution rate was observed
when FD was prepared with polysaccharide containing a surfactant. These results
confirmed that modified FDs are useful for treating localized conditions in the
oral cavity, such as oral candidiasis, and that FDs can simplify the
administration of drugs to patients.