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has been cited by the following article:

• TITLE: Reduced expression of COMT in placenta correlates with term preeclampsia

  AUTHORS: Baoling Lai, Chenhong Wang, Lu Zhou, Jie Wang, Huifen Wu

  KEYWORDS: Catechol-O-Methyltransferase; Preeclampsia; Placenta

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.4A, April 30, 2013

  ABSTRACT: Objective: To investigate the expression of catechol-O- methyltransferase (COMT) in placentas from term preeclampsia patients in a Chinese cohort and to analyze the relationships between COMT and mean artery pressure (MAP), serum uric acid and 24-hour urine protein. Methods: 15 term pregnant patients with preeclampsia and 15 normal pregnant women were enrolled. Clinical characteristics and placental tissue were collected. Placental COMT expression was determined by quantitative real-time PCR technique and immunohistochemistry. Results: The level of COMT mRNA in placentas from the preeclampsia group was significantly decreased than that in the normal pregnant women (0.00179 ± 0.00051 vs. 0.00289 ± 0.00066, t = 5.145, P 0.001). Adjusted by age and body mass index (BMI), the COMT expression was negatively correlated with serum uric acid (r = ?0.660, P r = ?0.717, P r = ?0.619, P