TITLE:
Plasma catalase, glutathione-s-transferase and total antioxidant activity levels of children with attention deficit and hyperactivity disorder
AUTHORS:
V. Kenan Çelik, Erdal Erşan, Serpil Erşan, Sevtap Bakır, Orhan Dogan
KEYWORDS:
ADHD; Catalase; Antioxidant Activity; Oxidative Stress; Glutathione-S-Transferase
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.2,
February
28,
2013
ABSTRACT:
Objective:
In this study, we plan to measure plasma Catalase
(CAT), Antioxidant Activity (AOA) and Glu- tathione-S-Transferase (GST)
levels to understand whether oxidative stress develops or not and whether or
not the detoxification mechanism properly functions in children with
Attention Deficit and Hyperactivity Disorder (ADHD) with unknown etiology and pathogenesis. Method and Results: Plasma
CAT, AOA, and GST activities were
spectrophotometrically measured in forty patients (average age 10.27 ±
2.54) and thirty-five (average age, 9.97 ± 2.59) healthy individuals as the
control group. While the CAT activity showed no difference in the patient group
(P > 0.05) compared to the control group, AOA and GST levels were found
significantly meaningful (P = 0.001). Conclusion: In this pilot study ,the
study shows that no oxidative stress develops in individuals with ADHD in high
AOA and stable CAT activity, and that the de- toxification mechanism functions extremely
in high GST activity. These findings need to be supported by other studies.