A. Leffler, A. Lattrell, S. Kronewald, F. Niedermirtl and C. Nau, “Activation of TRPA1 by Membrane Permeable Local Anesthetics,” Molecular Pain, Vol. 7, 2011, p. 62.

has been cited by the following article:

• TITLE: Why Labor Epidural Causes Fever and Why Lidocaine Burns on Injection? Role of TRPV 1 Receptor in Hyperthermia: Possible Explanation of Mechanism of Hyperthermia during Labor Epidural and Burning Sensation on Injection of Local Anesthetics

  AUTHORS: I. Kozlov

  KEYWORDS: Labor Epidural; Hyperthermia; Fever; Vanilloid Receptor; TPRV 1; Lidocaine; Local Anesthetics; Neurogenic Inflammation

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.2 No.4, September 4, 2012

  ABSTRACT: The mechanisms of epidural-associated fever remain incompletely understood [1-3]. We propose that action of local anesthetic on TPRV1. The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor can explain this effect and explain mechanism of burning sensation on local anesthetic injected subcutaneously or intramuscular. Role of TRPV1 receptor was not discussed previously in Obstetric Anesthesia literature. Based on available data, we propose that Local Anesthetics work as agonist/antagonist on TPRV1 receptors. Antagonist action may cause hyperthermia through modifying thermoregulation [4], agonist action may cause hyperthermia thru release of IL-6 and other mediators of inflammation [5-10]. Agonist action may explain burning sensation on injection of Local Anesthetics. Burning sensation can be diminished by increasing pH of Local Anesthetic solution, because vanillin receptors are stimulated by acidification through lower pH [11,12].