Kaazempur-Mofrad, M.R., Bathe, M., Karcher, H., Younis, H.F., Seong, H.C., Shim, E.B., Chan, R.C., Hinton, D.P., Isasi, A.G., Upadhyaya, A., Powers, M.J., Griffith, L.G. and Kamm, R.D. (2003) Role of simulation in understanding biological systems. Computers & Structures, 81, 715-726. doi:10.1016/S0045-7949(02)00481-9

has been cited by the following article:

• TITLE: Quantification of the distribution of blood flow pressure with postures

  AUTHORS: Wenying Mu, Shanguang Chen, Fengyuan Zhuang, Yinghui Li, Yu Li

  KEYWORDS: Distribution of Blood Flow Pressure (DBFP); Posture; Gravity; Numerical Simulation

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.5 No.3, March 27, 2012

  ABSTRACT: At a different angle, this study analyzed the contour chart of blood flow pressure, extreme pressure and its position to quantify DBFP in thirteen different postures with gravity considered or not (G ≠ 0 or G = 0). The aim was to determine the suitable body positions, in which the postural model of a single vessel could be simplified to two-dimensional (2D) symmetrical one while only considering such factors as posture and gravity. Computational fluid dynamic simulations were performed. Numerical results demonstrated that the DBFP showed 2D axisymmetry at ±90° and three-dimensional (3D) asymmetry at any other posture with G ≠ 0, and 2D axisymmetrical one at any posture with G = 0. Therefore, modeling a vessel as a 2D model is feasible in space and at ±90° posture on earth. In addition, the maximum pressure occurred between the inlet and the middle of the vessel, and its position variation mainly happened in the range of 0° - 15°. For a single vessel, this study provides the first theoretical evidence for cardiovascular modeling in microgravity and may help guide the researchers in designing defense devices for astronauts or patients clinically.