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has been cited by the following article:

• TITLE: Mitochondria: transportation, distribution and function during spermiogenesis

  AUTHORS: Xiao Sun, Wan-Xi Yang

  KEYWORDS: Spermiogenesis; Mitochondria; Molecular Motors; Sperm Motility; Ubiquitination; Infertility

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.1 No.2, June 30, 2010

  ABSTRACT: Spermiogenesis is a dynamic process which includes organelle reorganization and new structure formation. The morphology and distribution of the mitochondria in germ cells change to accommodate the cellular requirement. Multiple molecular motors and related proteins participate in carrying and anchoring mitochondria to the midpiece during spermiogenesis and this process is regulated precisely. Energetic metabolism provides energy for cellular activity and influences sperm survival and motility directly. Ubiquitination of mitochondria takes place during spermiogenesis, which has been implicated in sperm quality control and mitochondrial inheritance. In light of the essential roles of mitochondria in energy production, calcium homeostasis and apoptosis, mitochondria dysfunction cause severe human diseases, such as male infertility. The present study paves a way for a more detailed exploration of the biology of mitochondria during spermiogenesis.