Ajala, A.O. and Okoro, C.O. (2011) CoMFA and CoMSIA Studies on Fluorinated Hexahydropyrimidine Derivatives. Bioorganic & Medicinal Chemistry Letters, 21, 7392-7398.
https://doi.org/10.1016/j.bmcl.2011.10.008

has been cited by the following article:

• TITLE: Facile Synthesis of Bis-Trifluoromethyl 1,8-Dioxo-Octahydroxanthene Derivatives

  AUTHORS: Cosmas O. Okoro, Mumiye A. Ogunwale, Abiodun S. Oyedele

  KEYWORDS: Xanthenedione, Aromatic Aldehyde, Cyclic β-Diketone, 5-Trifluoromethyl

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.9 No.3, August 13, 2019

  ABSTRACT: Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione derivatives. The reaction of two equivalents of 5-trifluoromethyl cyclohexane-1,3- dione with substituted aromatic aldehydes in the presence of ethanol containing 1 - 2 drops of HCl was facile under microwave irradiation. Short reaction time (25 min), good to excellent yields (80% - 95%), good atom economy, and simple workup are the major advantages of the above procedure. Moreover, the fluorinated products represent synthetically useful stable intermediates that could find applications in pharmaceutical, agricultural and material industries.