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Ho, C.L., Su, W.C., Hsieh, R.K., Lin, Z.Z. and Chao, T.Y. (2010) A Randomized, Double-Blind, Parallel, Comparative Study to Evaluate the Efficacy and Safety of Ramosetron plus Dexamethasone Injection for the Prevention of Acute Chemotherapy-Induced Nausea And Vomiting. Japanese Journal of Clinical Oncology, 40, 294-301.
https://doi.org/10.1093/jjco/hyp169

has been cited by the following article:

  • TITLE: Effect of Antiemetic Agents on Hiccups during Chemotherapy in Patients with Lung Cancer

    AUTHORS: Shinya Toriumi, Kazuharu Nakazawa, Masaru Shoji

    KEYWORDS: Hiccups, Dexamethasone, Neurokinin-1 Receptor Antagonist, Antiemetic Agents, Lung Cancer

    JOURNAL NAME: Pharmacology & Pharmacy, Vol.9 No.4, April 30, 2018

    ABSTRACT: Hiccups commonly occur in patients undergoing chemotherapy for lung cancer and may diminish their motivation for treatment. Therefore, it is important to characterize the hiccups and their risk factors. We examined the medical records of 120 patients with lung cancer during their initial chemotherapy and extracted data on the patients’ profiles and the onset, duration, and severity of their hiccup episodes. We found the incidence of hiccups to be 19.2% among the patients. Hiccups appeared within 3 days of beginning the chemotherapy and disappeared within 4 days. Hiccups hindered sleep in two patients. The characteristics of the hiccups episodes in our study were not different from those of previous studies. We also investigated distinctive features of the patients who developed hiccups. The occurrence of hiccups was associated with gender, age, and the treatment with platinum agents. Antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists, also showed significant effects on hiccup episodes. Although the dose-responsive effect of dexamethasone on hiccups was insignificant and the effects of two neurokinin-1 receptor antagonists, aprepitant and fosaprepitant, on hiccups appeared identical. From these results, we suggest that a high incidence of hiccups may be anticipated with a prophylactic use of antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists.