TITLE:
Interplay between Platelet Endothelial Cell Adhesion Molecule-1 and Pigment Epithelium-Derived Factor in Non-Small-Cell-Lung Cancer
AUTHORS:
Alexander Emmert, Angelika Oellerich, Laszlo Füzesi, Regina Waldmann- Beushausen, Friedrich A. Schöndube, Hanibal Bohnenberger, Bernhard C. Danner
KEYWORDS:
NSCLC, PEDF, PECAM-1, Neoangiogenesis
JOURNAL NAME:
Open Journal of Thoracic Surgery,
Vol.6 No.4,
December
9,
2016
ABSTRACT: Pigment epithelium-derived factor (PEDF), a potent antiangiogenesis agent, is a
multifunctional protein with important roles in regulation of inflammation and angiogenesis.
It has recently attracted attention for targeting tumor cells in several types
of tumors. PECAM-1 is an integral membrane protein, a cell adhesion molecule with
proangiogenic activity and plays an important role in the process of angiogenesis.
The correlation between proangiogenic activity PECAM-1 and antiangiogenic activity
PEDF in Non-Small-Cell-Lung Cancer has not been reported. The present study
was designed to evaluate using immunohistochemical techniques and multivariate
analysis the interplay between PECAM-1 and PEDF in NSCLC, especially in adenocarcinoma
and in squamous cell carcinoma stage IA-IIIB. Analyzing the mixed study
collectively (n = 69), there was no significant correlation (p = 0.553) between PECAM-1
signal and PEDF area. Only including patients with adenocarcinoma (Figure 2), we
found a positive correlation between PECAM-1 signal and PEDF area (p = 0.025). In
patients with squamous cell carcinoma, we did not find a significant correlation between
PECAM-1 signal and PEDF area (p = 0.530). In patients with squamous cell
carcinoma, PECAM-1 and PEDF show a significant different expression pattern,
measured via staining intensity (p = 0.013). These results might support the hypothesis
that squamous cell carcinomas heavily rely on angiogenic processes.