TITLE:
Microwave Application and Anhydrous Cu(OAc)2 Mediated O-Arylation of Aliphatic Amino Alcohols
AUTHORS:
Mohammad Al-Masum, Linda Quinones, Laurance T. Cain
KEYWORDS:
Hydroxylamine, Amino Ether, O-Arylation, O-Styrylation, Microwave
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.6 No.2,
May
27,
2016
ABSTRACT: Anhydrous Cu(OAc)2 mediated efficient protocol has been developed in the area of C-O coupling from potassium aryltrifluoroborates and aliphatic amino alcohols such as β-hydroxy, γ-hydroxy, and δ-hydroxy amines. The scope of this transformation focuses on direct O-arylation and O-styrylation. The reaction vial loaded with reactants under argon atmosphere is microwaved at 140°C for 30 min to furnish the corresponding cross-coupling product, amino ethers, in good yields.