Komeda, M., Ozaki, A., Hayashi, K., Sumimoto, M., Hori, K., Sugimoto, T. and Yamamoto, H. (2015) The Effective Catalyst (Cobalt Salt/Lewis Acid) for Beckmann Rearrangement of Cycloalkanone Oximes to Lactams under Mild Conditions. International Journal of Organic Chemistry, 5, 57-62.
http://dx.doi.org/10.4236/ijoc.2015.52007

has been cited by the following article:

• TITLE: Low Environmental Load Process for the Beckmann Rearrangement of Cycloalkanone Oximes by Brønsted Acid Catalyst with Cobalt Salts

  AUTHORS: Hidetoshi Yamamoto, Masahiro Komeda, Ayana Ozaki, Michinori Sumimoto, Kenji Hori, Tsunemi Sugimoto

  KEYWORDS: Beckmann Rearrangement, Cycloalkanone Oximes, Lactam, Cobalt Catalysts, Brønsted Acids

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.5 No.3, August 21, 2015

  ABSTRACT: Beckmann rearrangements of oximes to lactams often require harsh conditions and/or the use of large amounts of acid catalyst. To reduce the amount of Bronsted acid required, and to avoid the formation of a large amount of undesirable byproducts under mild reaction conditions, a low environmental load process was developed. Beckmann rearrangements of cyclohexanone oxime and cyclooctanone oxime were achieved using a combination of a Bronsted acid and cobalt tetra-fluoroborate hexahydrate. Various Bronsted acid catalysts (10 - 20 mol%) were used to obtain the corresponding lactams in high yields at 80℃.