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http://dx.doi.org/10.1016/j.biomaterials.2010.12.059

has been cited by the following article:

• TITLE: Using the Electromagnetics of Cancer’s Centrosome Clusters to Attract Therapeutic Nanoparticles

  AUTHORS: Ronald L. Huston

  KEYWORDS: Centrioles, Supernumerary Centrioles, Cell Electromagnetism, Theraputic Nanoparticles, Tumorigenesis, Cancer

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.6 No.3, March 19, 2015

  ABSTRACT: This paper summarizes recent research findings concerning centrioles, centriole duplication, centriole overduplication, supernumerary centrioles, centrosomes, and centrosome amplification. The paper then discusses the status of ongoing research on the use of nanoparticles for cancer treatment. The research findings show that a centriole produces an electromagnetic field apparently due to the longitudinal oscillation of its microtubules (MTs). A cluster of centrioles is therefore presumed to produce an enhanced electromagnetic field. Individual centrioles are immersed in a cloud of electron-dense material (proteins) which together with the centrioles is known as the centrosome. A cluster of centrioles thus produces a cluster of centrosomes—a hallmark of cancer cells. With enhanced electromagnetic fields, centrosome clusters provide an attraction for magnetically charged nanoparticles. These nanoparticles however are not attracted to normal cells which with only two (or at most four) centrioles, have a weaker magnetic field. The idea is simple: Magnetized and therapeutic nanoparticles are directed toward tumors and then attracted to the centrosome clusters of the tumor cells. Once inside the tumor cells, the nanoparticles can release their toxins.