TITLE:
Echocardiographic Parameters as Cardiovascular Mortality Predictors in Chronic Hemodialysis Patients
AUTHORS:
Misato Koeda, Tetsuya Ogawa, Kyoko Ito, Takaaki Tsutsui, Kosaku Nitta
KEYWORDS:
Diastolic Dysfunction, Echocardiography, Hemodialysis, Cardiovascular Mortality, Prognosis
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.12,
June
20,
2014
ABSTRACT:
Background: Hemodialysis (HD)
patients have high rates of cardiovascular (CV) mortality. Although
structural and functional echocardiographic alterations in HD patients have
been the subject of several survival analysis studies, the prognostic value
of these alterations is not well established. The aim of this study was to
determine the prognostic value of echocardiographic parameters in chronic HD
patients. Objectives: One hundred eighteen HD patients were clinically evaluated
and underwent Doppler echocardiography, being followed for 45.7 ± 13.6 months.
The outcome measures were CV mortality. The predictive value of
echocardiographic variables was evaluated by Cox regression model and survival
curves were constructed using the Kaplan-Meier method and log-rank test to compare
them. Results: CV diseases accounted for 46.4% of all deaths during the
follow-up period. We found that the event-free survival rates in one and two
years were 96.5% and 83.0%, respectively. Diabetes and E/e' ratio were
predictors of CV outcome by multivariate analyses. Conclusion: Diabetes and
diastolic dysfunction are independent predictors of CV mortality in chronic HD
patients.