Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK)

Changsha,China,10.16-10.18,2010

ISBN: 978-1-935068-41-9 Scientific Research Publishing, USA

E-Book 2313pp Pub. Date: October 2010

Category: Chemistry & Materials Science

Price: $360

Title: Comparative Studies of Influence of PP Electret Polarities in Skin Structure
Source: Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK) (pp 1358-1360)
Author(s): Lin Ma, Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433,
Yuan-yuan Liang, Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433,
Fa-jie Dong, Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433,
Li-li Cui, Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China
Ye Tu, Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China
Jian Jiang, Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433,
Abstract: The ±1000V polypropylene (PP) electrets were prepared by means of corona charging method. The skin structure changes were observed after the application of ±1000V PP electrets on rat abdominal skin using inverted phase contrast microscope. The results indicated that both the positive and negative PP electrets could change the microstructure of rat skin. Compared with +1000V PP electret, -1000V PP electret had more effect on disruption of arrangement of lipid layer which could more significantly to reduce the barrier function of skin stratum corneum. Therefore, -1000V electret could be used in transdermal delivery formulation to increase the drug permeation through skin.
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