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Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK)

Changsha,China,10.16-10.18,2010

ISBN: 978-1-935068-41-9 Scientific Research Publishing, USA

E-Book 2313pp Pub. Date: October 2010

Category: Chemistry & Materials Science

Price: $360

Title: Study on Mechanism of Preventing Tendon Adhesion by CTSb Compound Membrane
Source: Proceedings of the 7th National Conference on Functional Materials and Applications (FMA 2010 E-BOOK) (pp 453-457)
Author(s): Jing Chang, College of Marine Life Science, Ocean University of China, Qingdao, China
Wan-shun Liu, College of Marine Life Science, Ocean University of China, Qingdao, China
Bao-qin Han, College of Marine Life Science, Ocean University of China, Qingdao, China
Ye Liang, College of Marine Life Science, Ocean University of China, Qingdao, China
Hai-dong Cui, Qingdao Biotemed Biomaterial Co., Ltd. Qingdao, China
Abstract: L929 fibroblasts are cultured by blend solution of chitosan derivatives (CTSb solution). The effect of the CTSb solution on L929 fibroblasts is evaluated by methods of MTT, GE and so on. The mechanism of CTSb compound membrane preventing tendon adhesion is investigated by the study on CTSb solution on L929 fibroblasts. The results show that the growth of L929 fibroblasts is inhibited obviously after cultured by CTSb solution. Along with the concentration of the CTSb solution gets higher, the inhibitory effect becomes more evident. The cell cycle of L929 fibroblasts has been discontinued and the fibroblasts are blocked in G0-G1 period. The secretion of growth factor TGF-β1 and aFGF is also inhibited by CTSb solution. The results hint that CTSb compound membrane produces its preventing adhesion effect by inhibiting the growth of fibroblasts.
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