[1]
|
Centers for Disease Control and Prevention (2015) High Cholesterol Facts. https://www.cdc.gov/cholesterol/facts.htm
|
[2]
|
Bibbins-Domingo, K., Grossman, D.C., Curry, S.J., Davidson, K.W., Epling, J.W., García, F.A.R., et al. (2016) Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. JAMA, 316, 625-633. https://doi.org/10.1001/jama.2016.9852
|
[3]
|
Gultom, L.C., Sjarif, D.R., Sudoyo, H.A., Mansyur, M., Hadinegoro, S.R.S., Immanuel, S., et al. (2015) The Role of Apolipoprotein E Polymorphism in Improving Dyslipidemia in Obese Adolescents Following Physical Exercise and National Cholesterol Education Program Step II Intervention. Journal of Pediatric Endocrinology and Metabolism, 28, 597-603. https://doi.org/10.1515/jpem-2014-0070
|
[4]
|
Asselbergs, F.W., Guo, Y., van Iperen, E.P.A., Sivapalaratnam, S., Tragante, V., Lanktree, M.B., et al. (2012) Large-Scale Gene-Centric Meta-Analysis across 32 Studies Identifies Multiple Lipid Loci. The American Journal of Human Genetics, 91, 823-838. https://doi.org/10.1016/j.ajhg.2012.08.032
|
[5]
|
Goldberg, A.C., Hopkins, P.N., Toth, P.P., Ballantyne, C.M., Rader, D.J., Robinson, J.G., et al. (2011) Familial Hypercholesterolemia: Screening, Diagnosis and Management of Pediatric and Adult Patients. Journal of Clinical Lipidology, 5, 133-140. https://doi.org/10.1016/j.jacl.2011.03.001
|
[6]
|
Kavey, R.-E.W., Allada, V., Daniels, S.R., Hayman, L.L., McCrindle, B.W., Newburger, J.W., et al. (2006) Cardiovascular Risk Reduction in High-Risk Pediatric Patients. A Scientific Statement from the American Heart Association Expert Panel on Population and Prevention Science, the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease, and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics. Circulation, 114, 2710-2738. https://doi.org/10.1161/CIRCULATIONAHA.106.179568
|
[7]
|
Marks, D., Thorogood, M., Neil, H.A.W. and Humphries, S.E. (2003) A Review on the Diagnosis, Natural History, and Treatment of Familial Hypercholesterolaemia. Atherosclerosis, 168, 1-14. https://doi.org/10.1016/S0021-9150(02)00330-1
|
[8]
|
Pang, J., Martin, A.C., Mori, T.A., Beilinm, L.J. and Watts, G.F. (2016) Prevalence of Familial Hypercholesterolemia in Adolescents: Potential Value of Universal Screening? Journal of Pediatrics, 170, 315-316. https://doi.org/10.1016/j.jpeds.2015.11.019
|
[9]
|
Benn, M., Watts, G.F., Tybjærg-Hansen, A. and Nordestgaard, B.G. (2016) Mutations Causative of Familial Hypercholesterolaemia: Screening of 98,098 Individuals from the Copenhagen General Population Study Estimated a Prevalence of 1 in 217. European Heart Journal, 37, 1384-1394. https://doi.org/10.1093/eurheartj/ehw028
|
[10]
|
de Ferranti, S.D., Rodday, A.M., Mendelson, M.M., Wong, J.B., Leslie, L.K. and Sheldrick, R.C. (2016) Prevalence of Familial Hypercholesterolemia in the 1999 to 2012 United States National Health and Nutrition Examination Surveys (NHANES). Circulation, 133, 1067-1072. https://doi.org/10.1161/CIRCULATIONAHA.115.018791
|
[11]
|
Ademi, Z., Watts, G.F., Pang, J., Sijbrands, E.J.G., van Bockxmeer, F.M., O’Leary, P., et al. (2014) Cascade Screening Based on Genetic Testing Is Cost-Effective: Evidence for the Implementation of Models of Care for Familial Hypercholesterolemia. Journal of Clinical Lipidology, 8, 390-400. https://doi.org/10.1016/j.jacl.2014.05.008
|
[12]
|
Nordestgaard, B.G., Chapman, M.J., Humphries, S.E., Ginsberg, H.N., Masana, L., Descamps, O.S., et al. (2013) Familial Hypercholesterolaemia Is Underdiagnosed and Undertreated in the General Population: Guidance for Clinicians to Prevent Coronary Heart Disease Consensus Statement of the European Atherosclerosis Society. European Heart Journal, 34, 3478-3490. https://doi.org/10.1093/eurheartj/eht273
|
[13]
|
Santos, R.D., Gidding, S.S., Hegele, R.A., Cuchel, M.A., Barter, P.J., Watts, G.F., et al. (2016) Defining Severe Familial Hypercholesterolaemia and the Implications for Clinical Management: A Consensus Statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Lancet Diabetes and Endocrinology, 4, 850-861. https://doi.org/10.1016/S2213-8587(16)30041-9
|
[14]
|
Leigh, S., Futema, M., Whittall, R., Taylor-Beadling, A., Williams, M., den Dunnen, J.T., et al. (2017) The UCL Low-Density Lipoprotein Receptor Gene Variant Database: Pathogenicity Update. Journal of Medical Genetics, 54, 17-23. https://doi.org/10.1136/jmedgenet-2016-104054
|
[15]
|
Ross, J.L. (2016) Statins in the Management of Pediatric Dyslipidemia. Journal of Pediatric Nursing, 31, 723-735. https://doi.org/10.1016/j.pedn.2016.07.004
|
[16]
|
Futema, M., Shah, S., Cooper, J.A., Li, K., Whittall, R.A., Sharifi, M., et al. (2015) Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries. Clinical Chemistry, 61, 231-238. https://doi.org/10.1373/clinchem.2014.231365
|
[17]
|
Futema, M., Whittall, R.A., Kiley, A., Steel, L.K., Cooper, J.A., Badmus, E., et al. (2013) Analysis of the Frequency and Spectrum of Mutations Recognised to Cause Familial Hypercholesterolaemia in Routine Clinical Practice in a UK Specialist Hospital Lipid Clinic. Atherosclerosis, 229, 161-168. https://doi.org/10.1016/j.atherosclerosis.2013.04.011
|
[18]
|
Al Kindi, M., Bélanger, A.M., Sayegh, K., Senouci, S., Aljenedil, S., Sivakumaran, L., et al. (2017) Aortic Calcification Progression in Heterozygote Familial Hypercholesterolemia. Canadian Journal of Cardiology, 33, 658-665. https://doi.org/10.1016/j.cjca.2017.02.001
|
[19]
|
Al-Shaikh, A.M., Abdullah, M.H., Barclay, A., Cullen-Dean, G. and McCrindle, B.W. (2002) Impact of the Characteristics of Patients and Their Clinical Management on Outcomes in Children with Homozygous Familial Hypercholesterolemia. Cardiology in the Young, 12, 105-112. https://doi.org/10.1017/S1047951102000240
|
[20]
|
Fantus, D., Awan, Z., Seidah, N.G. and Genest, J. (2013) Aortic Calcification: Novel Insights from Familial Hypercholesterolemia and Potential Role for the Low-Density Lipoprotein Receptor. Atherosclerosis, 226, 9-15. https://doi.org/10.1016/j.atherosclerosis.2012.08.026
|
[21]
|
Neil, A., Cooper, J., Betteridge, J., Capps, N., McDowell, I., Durrington, P., et al. (2008) Reductions in All-Cause, Cancer, and Coronary Mortality in Statin-Treated Patients with Heterozygous Familial Hypercholesterolaemia: A Prospective Registry Study. European Heart Journal, 29, 2625-2633. https://doi.org/10.1093/eurheartj/ehn422
|
[22]
|
Awan, Z., Alrasadi, K., Francis, G.A., Hegele, R.A., McPherson, R., Frohlich, J., et al. (2008) Vascular Calcifications in Homozygote Familial Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 777-785. https://doi.org/10.1161/ATVBAHA.107.160408
|
[23]
|
Khera, A.V., Won, H.-H., Peloso, G.M., Lawson, K.S., Bartz, T.M., Deng, X., et al. (2016) Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. Journal of the American College of Cardiology, 67, 2578-2589. https://doi.org/10.1016/j.jacc.2016.03.520
|
[24]
|
Mallika, V., Goswami, B. and Rajappa, M. (2007) Atherosclerosis Pathophysiology and the Role of Novel Risk Factors: A Clinicobiochemical Perspective. Angiology, 58, 513-522. https://doi.org/10.1177/0003319707303443
|
[25]
|
Berenson, G.S., Srinivasan, S.R., Bao, W., Newman, W.P., Tracy, R.E. and Wattigney, W.A. (1998) Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults. The New England Journal of Medicine, 338, 1650-1656. https://doi.org/10.1056/NEJM199806043382302
|
[26]
|
Moore, K.J. and Tabas, I. (2011) Macrophages in the Pathogenesis of Atherosclerosis. Cell, 145, 341-355. https://doi.org/10.1016/j.cell.2011.04.005
|
[27]
|
Stary, H.C., Chandler, A.B., Glagov, S., Guyton, J.R., Insull, W., Rosenfeld, M.E., et al. (1994) A Definition of Initial, Fatty Streak, and Intermediate Lesions of Atherosclerosis. A Report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation, 89, 2462-2478. https://doi.org/10.1161/01.CIR.89.5.2462
|
[28]
|
Libby, P., Ridker, P.M. and Hansson, G.K. (2009) Inflammation in Atherosclerosis: From Pathophysiology to Practice. Journal of the American College of Cardiology, 54, 2129-2138. https://doi.org/10.1016/j.jacc.2009.09.009
|
[29]
|
Rudzka, D.A., Cameron, J.M. and Olson, M.F. (2015) Reactive Oxygen Species and Hydrogen Peroxide Generation in Cell Migration. Communicative & Integrative Biology, 8, e1074360.
|
[30]
|
Steinberg, D. (1997) Lewis, A. Conner Memorial Lecture. Oxidative Modification of LDL and Atherogenesis. Circulation, 95, 1062-1071. https://doi.org/10.1161/01.CIR.95.4.1062
|
[31]
|
Brown, M.S. and Goldstein, J.L. (1983) Lipoprotein Metabolism in the Macrophage: Implications for Cholesterol Deposition in Atherosclerosis. Annual Review of Biochemistry, 52, 223-261. https://doi.org/10.1146/annurev.bi.52.070183.001255
|
[32]
|
Van Gaal, L.F., Mertens, I.L. and De Block, C.E. (2006) Mechanisms Linking Obesity with Cardiovascular Disease. Nature, 444, 875-880. https://doi.org/10.1038/nature05487
|
[33]
|
Stary, H.C., Chandler, A.B., Dinsmore, R.E., Fuster, V., Glagov, S., Insull, W., et al. (1995) A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. A Report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation, 92, 1355-1374. https://doi.org/10.1161/01.CIR.92.5.1355
|
[34]
|
Khoury, Z., Schwartz, R., Gottlieb, S, Chenzbraun, A., Stern, S. and Keren, A. (1997) Relation of Coronary Artery Disease to Atherosclerotic Disease in the Aorta, Carotid, and Femoral Arteries Evaluated by Ultrasound. American Journal of Cardiology, 80, 1429-1433. https://doi.org/10.1016/S0002-9149(97)00701-7
|
[35]
|
Bridger, T. (2009) Childhood Obesity and Cardiovascular Disease. Paediatrics & Child Health, 14, 177-182. https://doi.org/10.1093/pch/14.3.177
|
[36]
|
Wissler, RW. (1991) USA Multicenter Study of the Pathobiology of Atherosclerosis in Youtha. Annals of the New York Academy of Sciences, 623, 26-39. https://doi.org/10.1111/j.1749-6632.1991.tb43716.x
|
[37]
|
Wiegman, A., Gidding, S.S., Watts, G.F., Chapman, M.J., Ginsberg, H.N., Cuchel, M., et al. (2015) Familial Hypercholesterolaemia in Children and Adolescents: Gaining Decades of Life by Optimizing Detection and Treatment. European Heart Journal, 36, 2425-2437. https://doi.org/10.1093/eurheartj/ehv157
|
[38]
|
Groner, J.A., Joshi, M. and Bauer, J.A. (2006) Pediatric Precursors of Adult Cardiovascular Disease: Noninvasive Assessment of Early Vascular Changes in Children and Adolescents. Pediatrics, 118, 1683-1691. https://doi.org/10.1542/peds.2005-2992
|
[39]
|
Davis, P.H., Dawson, J.D., Riley, W.A. and Lauer, R.M. (2001) Carotid Intimal-Medial Thickness Is Related to Cardiovascular Risk Factors Measured from Childhood through Middle Age: The Muscatine Study. Circulation, 104, 2815-2819. https://doi.org/10.1161/hc4601.099486
|
[40]
|
Li, S., Chen, W., Srinivasan, S.R., Bond, M.G., Tang, R., Urbina, E.M., et al. (2003) Childhood Cardiovascular Risk Factors and Carotid Vascular Changes in Adulthood: The Bogalusa Heart Study. JAMA, 290, 2271-2276. https://doi.org/10.1001/jama.290.17.2271
|
[41]
|
Prastyanto, S., Sitaresmi, M.N. and Julia, M. (2014) Lipid Profiles in Smoking and Non-Smoking Male Adolescents. Paediatrica Indonesiana, 54, 232-235. https://doi.org/10.14238/pi54.4.2014.232-5
|
[42]
|
Meenakshisundaram, R., Rajendiran, C., Thirumalaikolundusubramanian P. (2010) Lipid and Lipoprotein Profiles among Middle Aged Male Smokers: A Study from Southern India. Tobacco Induced Diseases, 8, 11. https://doi.org/10.1186/1617-9625-8-11
|
[43]
|
Guedes, D.P., Guedes, J.E.R.P., Barbosa, D.S. and de Oliveira, J.A. (2007) Tobacco Use and Plasma Lipid-Lipoprotein Profile in Adolescents. Revista da Associação Médica Brasileira, 53, 59-63. https://doi.org/10.1590/S0104-42302007000100021
|
[44]
|
Hill, J.S., Hayden, M.R., Frohlich, J. and Pritchard, P.H. (1991) Genetic and Environmental Factors Affecting the Incidence of Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 11, 290-297. https://doi.org/10.1161/01.ATV.11.2.290
|
[45]
|
McGill, H.C. and McMahan, C.A. (1998) Determinants of Atherosclerosis in the Young. American Journal of Cardiology, 82, 30-36. https://doi.org/10.1016/S0002-9149(98)00720-6
|
[46]
|
Czerwinski, S.A., Mahaney, M.C., Rainwater, D.L., Vandeberg, J.L., MacCluer, J.W., Stern, M.P., et al. (2004) Gene by Smoking Interaction: Evidence for Effects on Low-Density Lipoprotein Size and Plasma Levels of Triglyceride and High-Density Lipoprotein Cholesterol. Human Biology, 76, 863-876. https://doi.org/10.1353/hub.2005.0014
|
[47]
|
Reilly, M., Delanty, N., Lawson, J.A. and FitzGerald, G.A. (1996) Modulation of Oxidant Stress in Vivo in Chronic Cigarette Smokers. Circulation, 94, 19-25. https://doi.org/10.1161/01.CIR.94.1.19
|
[48]
|
Valkonen, M. and Kuusi, T. (1998) Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein. Circulation, 97, 2012-2016. https://doi.org/10.1161/01.CIR.97.20.2012
|
[49]
|
Niki, E. (1991) Action of Ascorbic Acid as a Scavenger of Active and Stable Oxygen Radicals. The American Journal of Clinical Nutrition, 54, 1119S-1124S. https://doi.org/10.1093/ajcn/54.6.1119s
|
[50]
|
Frei, B. (1991) Ascorbic Acid Protects Lipids in Human Plasma and Low-Density Lipoprotein against Oxidative Damage. The American Journal of Clinical Nutrition, 54, 1113S-1118S.
|
[51]
|
Schectman, G., Byrd, J.C. and Gruchow, H.W. (1989) The Influence of Smoking on Vitamin C Status in Adults. American Journal of Public Health, 79, 158-162. https://doi.org/10.2105/AJPH.79.2.158
|
[52]
|
Celermajer, D.S., Adams, M.R., Clarkson, P., Robinson, J., McCredie, R., Donald, A., et al. (1996) Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults. The New England Journal of Medicine, 34, 150-155. https://doi.org/10.1056/NEJM199601183340303
|
[53]
|
McMurray, H.F., Parthasarathy, S. and Steinberg, D. (1993) Oxidatively Modified Low Density Lipoprotein Is a Chemoattractant for Human T Lymphocytes. The Journal of Clinical Investigation, 92, 1004-1008. https://doi.org/10.1172/JCI116605
|
[54]
|
Quinn, M.T., Parthasarathy, S., Fong, L.G. and Steinberg, D. (1987) Oxidatively Modified Low Density Lipoproteins: A Potential Role in Recruitment and Retention of Monocyte/Macrophages during Atherogenesis. Proceedings of the National Academy of Sciences of the United States of America, 84, 2995-2998. https://doi.org/10.1073/pnas.84.9.2995
|
[55]
|
Yang, B., Li, M., Chen, B., Xu, Y. and Li, T.-D. (2012) Deterioration of Endothelial Function and Carotid Intima-Media Thickness in Tibetan Male Adolescents Exposed to Second-Hand Smoke. Journal of the Renin-Angiotensin-Aldosterone System, 13, 413-419. https://doi.org/10.1177/1470320312440901
|
[56]
|
Barnoya, J. and Glantz, S.A. (2005) Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking. Circulation, 111, 2684-2698. https://doi.org/10.1161/CIRCULATIONAHA.104.492215
|
[57]
|
Kallio, K., Jokinen, E., Raitakari, O.T., Hämäläinen, M., Siltala, M., Volanen, I., et al. (2007) Tobacco Smoke Exposure Is Associated with Attenuated Endothelial Function in 11-Year-Old Healthy Children. Circulation, 115, 3205-3212. https://doi.org/10.1161/CIRCULATIONAHA.106.674804
|
[58]
|
Reriani, M.K., Lerman, L.O. and Lerman, A. (2010) Endothelial Function as a Functional Expression of Cardiovascular Risk Factors. Biomarkers in Medicine, 4, 351-360. https://doi.org/10.2217/bmm.10.61
|
[59]
|
Puranik, R. and Celermajer, D.S. (2003) Smoking and Endothelial Function. Progress in Cardiovascular Diseases, 45, 443-458. https://doi.org/10.1053/pcad.2003.YPCAD13
|
[60]
|
Miyazaki, H., Matsuoka, H., Cooke, J.P., Usui, M., Ueda, S., Okuda, S., et al. (1999) Endogenous Nitric Oxide Synthase Inhibitor: A Novel Marker of Atherosclerosis. Circulation, 99, 1141-1146. https://doi.org/10.1161/01.CIR.99.9.1141
|
[61]
|
Benowitz, N.L. and Jacob, P. (1994) Metabolism of Nicotine to Cotinine Studied by a Dual Stable Isotope Method. Clinical Pharmacology & Therapeutics, 56, 483-493. https://doi.org/10.1038/clpt.1994.169
|
[62]
|
Chen, W., Yun, M., Fernandez, C., Li, S., Sun, D., Lai, C.-C., et al. (2015) Secondhand Smoke Exposure Is Associated with Increased Carotid Artery Intima-Media Thickness: The Bogalusa Heart Study. Atherosclerosis, 240, 374-379. https://doi.org/10.1016/j.atherosclerosis.2015.04.002
|
[63]
|
Kosecik, M., Erel, O., Sevinc, E. and Selek, S. (2005) Increased Oxidative Stress in Children Exposed to Passive Smoking. International Journal of Cardiology, 100, 61-64. https://doi.org/10.1016/j.ijcard.2004.05.069
|
[64]
|
Aycicek, A., Erel, O. and Kocyigit, A. (2005) Increased Oxidative Stress in Infants Exposed to Passive Smoking. European Journal of Pediatrics, 164, 775-778. https://doi.org/10.1007/s00431-005-1720-1
|
[65]
|
Polidori, M.C., Mecocci, P., Stahl, W. and Sies, H. (2003) Cigarette Smoking Cessation Increases Plasma Levels of Several Antioxidant Micronutrients and Improves Resistance towards Oxidative Challenge. British Journal of Nutrition, 90, 147-150. https://doi.org/10.1079/BJN2003890
|
[66]
|
Cook, D. and Strachan, D. (1998) Parental Smoking, Bronchial Reactivity and Peak Flow Variability in Children. Thorax, 53, 295-301. https://doi.org/10.1136/thx.53.4.295
|
[67]
|
Kirkham, F.J., Prengler, M., Hewes, D.K. and Ganesan, V. (2000) Risk Factors for Arterial Ischemic Stroke in Children. Journal of Child Neurology, 15, 299-307. https://doi.org/10.1177/088307380001500506
|
[68]
|
Sträter, R., Becker, S., von Eckardstein, A., Heinecke, A., Gutsche, S., Junker, R., et al. (2002) Prospective Assessment of Risk Factors for Recurrent Stroke during Childhood—A 5-Year Follow-Up Study. Lancet, 360, 1540-1545. https://doi.org/10.1016/S0140-6736(02)11520-0
|
[69]
|
Nowak-Göttl, U., Sträter, R., Heinecke, A., Junker, R., Koch, H.G., Schuierer, G., et al. (1999) Lipoprotein (a) and Genetic Polymorphisms of Clotting Factor V, Prothrombin, and Methylenetetrahydrofolate Reductase are Risk Factors of Spontaneous Ischemic Stroke in Childhood. Blood, 94, 3678-3682.
|
[70]
|
Haywood, S., Liesner, R., Pindora, S. and Ganesan V. (2005) Thrombophilia and First Arterial Ischaemic Stroke: A Systematic Review. Archives of Disease in Childhood, 90, 402-405. https://doi.org/10.1136/adc.2004.049163
|
[71]
|
Laing, S.P., Swerdlow, A.J., Slater, S.D., Botha, J.L., Burden, A.C., Waugh, N.R., et al. (1999) The British Diabetic Association Cohort Study, II: Cause-Specific Mortality in Patients with Insulin-Treated Diabetes Mellitus. Diabetic Medicine, 16, 466-471. https://doi.org/10.1046/j.1464-5491.1999.00076.x
|
[72]
|
Donahue, R.P. and Orchard, T.J. (1992) Diabetes Mellitus and Macrovascular Complications: An Epidemiological Perspective. Diabetes Care, 15, 1141-1155. https://doi.org/10.2337/diacare.15.9.1141
|
[73]
|
Ebara, T., Conde, K., Kako, Y., Liu, Y., Xu, Y., Ramakrishnan, R., et al. (2000) Delayed Catabolism of ApoB-48 Lipoproteins due to Decreased Heparan Sulfate Proteoglycan Production in Diabetic Mice. Journal of Clinical Investigation, 105, 1807-1818. https://doi.org/10.1172/JCI8283
|
[74]
|
Cree-Green, M., Maahs, D.M., Ferland, A., Hokanson, J.E., Wang, H., Pyle, L., et al. (2016) Lipoprotein Subfraction Cholesterol Distribution Is More Atherogenic in Insulin Resistant Adolescents with Type 1 Diabetes. Pediatric Diabetes, 17, 257-265. https://doi.org/10.1111/pedi.12277
|
[75]
|
Thomas, N.E., Rowe, D.A., Murtagh, E.M., Stephens, J.W. and Williams, R. (2018) Associations between Metabolic Syndrome Components and Markers of Inflammation in Welsh School Children. European Journal of Pediatrics, 177, 409-417.
|
[76]
|
Fagot-Campagna, A., Knowler, W.C. and Pettitt, D.J. (1998) Type 2 Diabetes in Pima Indian Children: Cardiovascular Risk Factors at Diagnosis and 10 Years Later. Diabetes, 47.
|
[77]
|
Stout, R.W., Bierman, E.L. and Ross, R. (1975) Effect of Insulin on the Proliferation of Cultured Primate Arterial Smooth Muscle Cells. Circulation Research, 36, 319-327. https://doi.org/10.1161/01.RES.36.2.319
|
[78]
|
Landsberg, L. (1992) Hyperinsulinemia: Possible Role in Obesity-Induced Hypertension. Hypertension, 19, I61. https://doi.org/10.1161/01.HYP.19.1_Suppl.I61
|
[79]
|
Haller, M.J., Samyn, M., Nichols, W.W., Brusko, T., Wasserfall, C., Schwartz, R.F., et al. (2004) Radial Artery Tonometry Demonstrates Arterial Stiffness in Children with Type 1 Diabetes. Diabetes Care, 27, 2911-2917. https://doi.org/10.2337/diacare.27.12.2911
|
[80]
|
Heier, M., Stensæth, K.H., Brunborg, C., Seljeflot, I., Margeirsdottir, H.D., Hanssen, K.F., et al. (2017) Increased Arterial Stiffness in Childhood Onset Diabetes: A Cardiovascular Magnetic Resonance Study. European Heart Journal—Cardiovascular Imaging, jex178. https://doi.org/10.1093/ehjci/jex178
|
[81]
|
Harris, S.B., Ekoé, J.-M., Zdanowicz, Y. and Webster-Bogaert, S. (2005) Glycemic Control and Morbidity in the Canadian Primary Care Setting (Results of the Diabetes in Canada Evaluation Study). Diabetes Research and Clinical Practice, 70, 90-97. https://doi.org/10.1016/j.diabres.2005.03.024
|
[82]
|
Witztum, J.L. and Steinberg, D. (2001) The Oxidative Modification Hypothesis of Atherosclerosis: Does It Hold for Humans? Trends in Cardiovascular Medicine, 11, 93-102. https://doi.org/10.1016/S1050-1738(01)00111-6
|
[83]
|
Kontush, A., Chantepie, S. and Chapman, M.J. (2003) Small, Dense HDL Particles Exert Potent Protection of Atherogenic LDL against Oxidative Stress. Arteriosclerosis, Thrombosis, and Vascular Biology, 23, 1881-1888. https://doi.org/10.1161/01.ATV.0000091338.93223.E8
|
[84]
|
Wood, R.J., Volek, J.S., Liu, Y., Shachter, N.S., Contois, J.H. and Fernandez, M.L. (2006) Carbohydrate Restriction Alters Lipoprotein Metabolism by Modifying VLDL, LDL, and HDL Subfraction Distribution and Size in Overweight Men. The Journal of Nutrition, 136, 384-389. https://doi.org/10.1093/jn/136.2.384
|
[85]
|
Maahs, D.M., Hokanson, J.E., Wang, H., Kinney, G.L., Snell-Bergeon, J.K., East, A., et al. (2010) Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women with Type 1 Diabetes and Insulin Resistance. Diabetes, 59, 1771-1779. https://doi.org/10.2337/db09-1626
|
[86]
|
Colhoun, H.M., Otvos, J.D., Rubens, M.B., Taskinen, M.R., Underwood, S.R. and Fuller, J.H. (2002) Lipoprotein Subclasses and Particle Sizes and Their Relationship with Coronary Artery Calcification in Men and Women with and without Type 1 Diabetes. Diabetes, 51, 1949-1956. https://doi.org/10.2337/diabetes.51.6.1949
|
[87]
|
Maahs, D., Dabelea, D., D’Agostino, R., Andrews, J., Shah, A., Crimmins, N., et al. (2013) Glucose Control Predicts 2-Year Change in Lipid Profile in Youth with Type 1 Diabetes. Journal of Pediatrics, 162, 101-107.
|
[88]
|
Heyman, E., Berthon, P., Youssef, H., Delamarche, A., Briard, D., Gamelin, F.X., et al. (2012) Metabolic Dysfunction in Late-Puberty Adolescent Girls with Type 1 Diabetes: Relationship to Physical Activity and Dietary Intakes. Diabetes & Metabolism, 38, 337-342. https://doi.org/10.1016/j.diabet.2012.03.001
|
[89]
|
Steinberger, J., Daniels, S.R., Eckel, R.H., Hayman, L., Lustig, R.H., McCrindle, B., et al. (2009) Progress and Challenges in Metabolic Syndrome in Children and Adolescents: A Scientific Statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular Nursing, and Council on Nutrition, Physical Activity, and Metabolism. Circulation, 119, 628-647. https://doi.org/10.1161/CIRCULATIONAHA.108.191394
|
[90]
|
Galili, O., Versari, D., Sattler, K.J., Olson, M.L., Mannheim, D., McConnell, J.P., et al. (2007) Early Experimental Obesity Is Associated with Coronary Endothelial Dysfunction and Oxidative Stress. American Journal of Physiology-Heart and Circulatory Physiology, 292, H904-H911. https://doi.org/10.1152/ajpheart.00628.2006
|
[91]
|
Túri, S., Friedman, A., Bereczki, C., Papp, F., Kovàcs, J., Karg, E., et al. (2003) Oxidative Stress in Juvenile Essential Hypertension. Journal of Hypertension, 21, 145-152. https://doi.org/10.1097/00004872-200301000-00024
|
[92]
|
Sinaiko, A.R., Steinberger, J., Moran, A., Prineas, R.J., Vessby, B., Basu, S., et al. (2005) Relation of Body Mass Index and Insulin Resistance to Cardiovascular Risk Factors, Inflammatory Factors, and Oxidative Stress during Adolescence. Circulation, 111, 1985-1991. https://doi.org/10.1161/01.CIR.0000161837.23846.57
|
[93]
|
Besseling, J., Kastelein, J.J.P., Defesche, J.C., Hutten, B.A. and Hovingh, G.K. (2015) Association between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus. JAMA, 313, 1029-1036. https://doi.org/10.1001/jama.2015.1206
|
[94]
|
Sattar, N., Preiss, D., Murray, H.M., Welsh, P., Buckley, B.M., de Craen, A.J., et al. (2010) Statins and Risk of Incident Diabetes: A Collaborative Meta-Analysis of Randomised Statin Trials. Lancet, 375, 735-742. https://doi.org/10.1016/S0140-6736(09)61965-6
|
[95]
|
Preiss, D., Seshasai, S.R.K., Welsh, P., Murphy, S.A., Ho, J.E., Waters, D.D., et al. (2011) Risk of Incident Diabetes with Intensive-Dose Compared with Moderate-Dose Statin Therapy: A Meta-Analysis. JAMA, 305, 2556-2564. https://doi.org/10.1001/jama.2011.860
|
[96]
|
Sattar, N. and Taskinen, M.-R. (2012) Statins Are Diabetogenic—Myth or Reality? Atherosclerosis Supplements, 13, 1-10. https://doi.org/10.1016/j.atherosclerosissup.2012.06.001
|
[97]
|
Mills, E.J., Wu, P., Chong, G., Ghement, I., Singh, S., Akl, E.A., et al. (2011) Efficacy and Safety of Statin Treatment for Cardiovascular Disease: A Network Meta-Analysis of 170,255 Patients from 76 Randomized Trials. QJM: An International Journal of Medicine, 104, 109-124. https://doi.org/10.1093/qjmed/hcq165
|
[98]
|
Cnop, M., Hannaert, J.C., Grupping, A.Y. and Pipeleers, D.G. (2002) Low Density Lipoprotein Can Cause Death of Islet β-Cells by Its Cellular Uptake and Oxidative Modification. Endocrinology, 143, 3449-3453. https://doi.org/10.1210/en.2002-220273
|
[99]
|
Roehrich, M.-E., Mooser, V., Lenain, V., Herz, J., Nimpf, J., Azhar, S., et al. (2003) Insulin-Secreting β-Cell Dysfunction Induced by Human Lipoproteins. Journal of Biological Chemistry, 278, 18368-18375. https://doi.org/10.1074/jbc.M300102200
|
[100]
|
Rütti, S., Ehses, J.A., Sibler, R.A., Prazak, R., Rohrer, L., Georgopoulos, S., et al. (2009) Low- and High-Density Lipoproteins Modulate Function, Apoptosis, and Proliferation of Primary Human and Murine Pancreatic β-Cells. Endocrinology, 150, 4521-4530. https://doi.org/10.1210/en.2009-0252
|
[101]
|
Fuentes, F., Alcala-Diaz, J.F., Watts, G.F., Alonso, R., Muñiz, O., Díaz-Díaz, J.L., et al. (2015) Statins Do Not Increase the Risk of Developing Type 2 Diabetes in Familial Hypercholesterolemia: The SAFEHEART Study. International Journal of Cardiology, 201, 79-84. https://doi.org/10.1016/j.ijcard.2015.07.107
|
[102]
|
Kannel, W.B. (1996) Blood Pressure as a Cardiovascular Risk Factor: Prevention and Treatment. JAMA, 275, 1571-1576. https://doi.org/10.1001/jama.1996.03530440051036
|
[103]
|
Juhola, J., Magnussen, C.G., Viikari, J.S.A., Kähönen, M., Hutri-Kähönen, N., Jula, A., et al. (2011) Tracking of Serum Lipid Levels, Blood Pressure, and Body Mass Index from Childhood to Adulthood: The Cardiovascular Risk in Young Finns Study. Journal of Pediatrics, 159, 584-590. https://doi.org/10.1016/j.jpeds.2011.03.021
|
[104]
|
Jungers, P., Massy, Z.A., Nguyen Khoa, T., Fumeron, C., Labrunie, M., Lacour, B., et al. (1997) Incidence and Risk Factors of Atherosclerotic Cardiovascular Accidents in Predialysis Chronic Renal Failure Patients: A Prospective Study. Nephrology Dialysis Transplantation, 12, 2597-2602. https://doi.org/10.1093/ndt/12.12.2597
|
[105]
|
Maggi, E., Bellazzi, R., Falaschi, F., Frattoni, A., Perani, G., Finardi, G., et al. (1994) Enhanced LDL Oxidation in Uremic Patients: An Additional Mechanism for Accelerated Atherosclerosis? Kidney International, 45, 876-883. https://doi.org/10.1038/ki.1994.115
|
[106]
|
Dharmarajan, S.H., Bragg-Gresham, J.L., Morgenstern, H., Gillespie, B.W., Li, Y., Powe, N.R., et al. (2017) State-Level Awareness of Chronic Kidney Disease in the U.S. American Journal of Preventive Medicine, 53, 300-307. https://doi.org/10.1016/j.amepre.2017.02.015
|
[107]
|
Boyd, G.S., Koenigsberg, J., Falkner, B., Gidding, S. and Hassink, S. (2005) Effect of Obesity and High Blood Pressure on Plasma Lipid Levels in Children and Adolescents. Pediatrics, 116, 442-446. https://doi.org/10.1542/peds.2004-1877
|
[108]
|
Cuspidi, C., Rescaldani, M., Sala, C. and Grassi, G. (2014) Left-Ventricular Hypertrophy and Obesity: A Systematic Review and Meta-Analysis of Echocardiographic Studies. Journal of Hypertension, 32, 16-25. https://doi.org/10.1097/HJH.0b013e328364fb58
|
[109]
|
Lai, C.-C., Sun, D., Cen, R., Wang, J., Li, S., Fernandez-Alonso, C., et al. (2014) Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure from Childhood on Adulthood Left Ventricular Remodeling Patterns: The Bogalusa Heart Study. Journal of the American College of Cardiology, 64, 1580-1587. https://doi.org/10.1016/j.jacc.2014.05.072
|
[110]
|
Li, X., Li, S., Ulusoy, E., Chen, W., Srinivasan, S.R. and Berenson, G.S. (2004) Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood: The Bogalusa Heart Study. Circulation, 110, 3488-3492. https://doi.org/10.1161/01.CIR.0000149713.48317.27
|
[111]
|
Toprak, A., Wang, H., Chen, W., Paul, T., Srinivasan, S. and Berenson, G. (2008) Relation of Childhood Risk Factors to Left Ventricular Hypertrophy (Eccentric or Concentric) in Relatively Young Adulthood (from the Bogalusa Heart Study). American Journal of Cardiology, 101, 1621-1625. https://doi.org/10.1016/j.amjcard.2008.01.045
|
[112]
|
Urbina, E.M., Gidding, S.S., Bao, W., Pickoff, A.S., Berdusis, K. and Berenson, G.S. (1995) Effect of Body Size, Ponderosity, and Blood Pressure on left Ventricular Growth in Children and Young Adults in the Bogalusa Heart Study. Circulation, 91, 2400-2406. https://doi.org/10.1161/01.CIR.91.9.2400
|
[113]
|
Dhuper, S., Abdullah, R.A., Weichbrod, L., Mahdi, E. and Cohen, H.W. (2011) Association of Obesity and Hypertension with Left Ventricular Geometry and Function in Children and Adolescents. Obesity, 19, 128-133. https://doi.org/10.1038/oby.2010.134
|
[114]
|
Mann, S., Beedie, C. and Jimenez, A. (2014) Differential Effects of Aerobic Exercise, Resistance Training and Combined Exercise Modalities on Cholesterol and the Lipid Profile: Review, Synthesis and Recommendations. Sports Medicine, 44, 211-221. https://doi.org/10.1007/s40279-013-0110-5
|
[115]
|
Pälve, K.S., Pahkala, K., Magnussen, C.G., Koivistoinen, T., Juonala, M., Kähönen, M., et al. (2014) Association of Physical Activity in Childhood and Early Adulthood with Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study. Journal of the American Heart Association, 3, e000594. https://doi.org/10.1161/JAHA.113.000594
|
[116]
|
Moreau, K.L., Donato, A.J., Seals, D.R., DeSouza, C.A. and Tanaka, H. (2003) Regular Exercise, Hormone Replacement Therapy and the Age-Related Decline in Carotid Arterial Compliance in Healthy Women. Cardiovascular Research, 57, 861-868. https://doi.org/10.1016/S0008-6363(02)00777-0
|
[117]
|
Nualnim, N., Barnes, J.N., Tarumi, T., Renzi, C.P. and Tanaka, H. (2011) Comparison of Central Artery Elasticity in Swimmers, Runners, and the Sedentary. American Journal of Cardiology, 107, 783-787. https://doi.org/10.1016/j.amjcard.2010.10.062
|
[118]
|
Gando, Y., Yamamoto, K., Murakami, H., Ohmori, Y., Kawakami, R., Sanada, K., et al. (2010) Longer Time Spent in Light Physical Activity Is Associated with Reduced Arterial Stiffness in Older Adults. Hypertension, 56, 540-546. https://doi.org/10.1161/HYPERTENSIONAHA.110.156331
|
[119]
|
McGavock, J.M., Anderson, T.J. and Lewanczuk, R.Z. (2006) Sedentary Lifestyle and Antecedents of Cardiovascular Disease in Young Adults. American Journal of Hypertension, 19, 701-707. https://doi.org/10.1016/j.amjhyper.2006.01.013
|
[120]
|
Maffeis, C., Fornari, E., Morandi, A., Piona, C., Tomasselli, F., Tommasi, M., et al. (2017) Glucose-Independent Association of Adiposity and Diet Composition with Cardiovascular Risk in Children and Adolescents with Type 1 Diabetes. Acta Diabetologica, 54, 599-605. https://doi.org/10.1007/s00592-017-0993-y
|
[121]
|
National Heart, Lung and Blood Institute (2011) Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents: Summary Report. Pediatrics, 128, S213-S256. https://doi.org/10.1542/peds.2009-2107C
|
[122]
|
Daniels, S.R. (2015) Pediatric Guidelines for Dyslipidemia. Journal of Clinical Lipidology, 9, S5-S10. https://doi.org/10.1016/j.jacl.2015.03.105
|
[123]
|
Bertrais, S., Balkau, B., Charles, M.A., Vol, S., Calvet, C., Tichet, J., et al. (2000) Puberty-Associated Differences in Total Cholesterol and Triglyceride Levels According to Sex in French Children Aged 10-13 Years. Annals of Epidemiology, 10, 316-323. https://doi.org/10.1016/S1047-2797(00)00056-9
|
[124]
|
Wagner, J. and Abdel-Rahman, S.M. (2016) Pediatric Statin Administration: Navigating a Fronteir with Limited Data. Journal of Pediatric Pharmacology and Therapeutics, 21, 380-403. https://doi.org/10.5863/1551-6776-21.5.380
|
[125]
|
Avis, H.J., Kusters, D.M., Vissers, M.N., Huijgen, R., Janssen, T.H., Wiegman, A., et al. (2012) Follow-Up of Children Diagnosed with Familial Hypercholesterolemia in a National Genetic Screening Program. Journal of Pediatrics, 161, 99-103. https://doi.org/10.1016/j.jpeds.2011.12.037
|
[126]
|
Ned, R.M. and Sijbrands, E.J.G. (2011) Cascade Screening for Familial Hypercholesterolemia (FH). PLoS Currents, 3, RRN1238. https://doi.org/10.1371/currents.RRN1238
|
[127]
|
Hovingh, G.K., Davidson, M.H., Kastelein, J.J.P. and O’Connor, A.M. (2013) Diagnosis and Treatment of Familial Hypercholesterolaemia. European Heart Journal, 34, 962-971. https://doi.org/10.1093/eurheartj/eht015
|
[128]
|
Civeira, F. (2004) Guidelines for the Diagnosis and Management of Heterozygous Familial Hypercholesterolemia. Atherosclerosis, 173, 55-68. https://doi.org/10.1016/j.atherosclerosis.2003.11.010
|
[129]
|
Williams, R.R., Hamilton-Craig, I., Kostner, G.M., Hegele, R.A., Hayden, M.R., Pimstone, S.N., et al. (1996) MED-PED: An Integrated Genetic Strategy for Preventing Early Deaths. In: Berg, K., Boulyjenkov, V. and Christen, Y., Eds., Genetic Approaches to Noncommunicable Diseases, Springer, Berlin, Heidelberg, 35-45. https://doi.org/10.1007/978-3-642-61028-8_5
|
[130]
|
Austin, M.A., Hutter, C.M., Zimmern, R.L. and Humphries, S.E. (2004) Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review. American Journal of Epidemiology, 160, 407-420. https://doi.org/10.1093/aje/kwh236
|
[131]
|
Scientific Steering Committee on Behalf of the Simon Broome Register Group. (1991) Risk of Fatal Coronary Heart Disease in Familial Hypercholesterolaemia. BMJ, 303, 893-896.
|
[132]
|
Humphries, S.E., Whittall, R.A., Hubbart, C.S., Maplebeck, S., Cooper, J.A., Soutar, A.K., et al. (2006) Genetic Causes of Familial Hypercholesterolaemia in Patients in the UK: Relation to Plasma Lipid Levels and Coronary Heart Disease Risk. Journal of Medical Genetics, 43, 943-949. https://doi.org/10.1136/jmg.2006.038356
|
[133]
|
McCrindle, B.W., Urbina, E.M., Dennison, B.A., Jacobson, M.S., Steinberger, J., Rocchini, A.P., et al. (2007) Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. Circulation, 115, 1948-1967. https://doi.org/10.1161/CIRCULATIONAHA.107.181946
|
[134]
|
de Jongh, S., Lilien, M.R., op’t Roodt, J., Stroes, E.S.G., Bakker, H.D. and Kastelein, J.J.P. (2002) Early Statin Therapy Restores Endothelial Function in Children with Familial Hypercholesterolemia. Journal of the American College of Cardiology, 40, 2117-2121. https://doi.org/10.1016/S0735-1097(02)02593-7
|
[135]
|
Penny, W.F., Ben-Yehuda, O., Kuroe, K., Long, J., Bond, A., Bhargava, V., et al. (2001) Improvement of Coronary Artery Endothelial Dysfunction with Lipid-Lowering Therapy: Heterogeneity of Segmental Response and Correlation with Plasma-Oxidized Low Density Lipoprotein. Journal of the American College of Cardiology, 37, 766-774. https://doi.org/10.1016/S0735-1097(00)01180-3
|
[136]
|
Masumoto, A., Hirooka, Y., Hironaga, K., Eshima, K., Setoguchi, S., Egashira, K, et al. (2001) Effect of Pravastatin on Endothelial Function in Patients with Coronary Artery Disease (Cholesterol-Independent Effect of Pravastatin). American Journal of Cardiology, 88, 1291-1294. https://doi.org/10.1016/S0002-9149(01)02090-2
|
[137]
|
Betteridge, D., Broome, K., Durrington, P., Hawkins, M., Humphries, S., Mann, J., et al. (1999) Mortality in Treated Heterozygous Familial Hypercholesterolaemia: Implications for Clinical Management. Atherosclerosis, 142, 105-112. https://doi.org/10.1016/S0021-9150(98)00200-7
|
[138]
|
Braamskamp, M.J.A.M., Langslet, G., McCrindle, B.W., Cassiman, D.M., Francis, G.A., Gagne, C., et al. (2017) Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children with Heterozygous Familial Hypercholesterolemia: The CHARON Study. Circulation, 136, 359-366.
|
[139]
|
Rodenburg, J., Vissers, M.N., Wiegman, A., van Trotsenburg, A.S.P., van der Graaf, A., de Groot, E., et al. (2007) Statin Treatment in Children with Familial Hypercholesterolemia: The Younger, the Better. Circulation, 116, 664-668. https://doi.org/10.1161/CIRCULATIONAHA.106.671016
|
[140]
|
Bradford, R.H., Shear, C.L., Chremos, A.N., Dujovne, C., Downton, M., Franklin, F.A., et al. (1991) Expanded Clinical Evaluation of Lovastatin (EXCEL) Study Results. I. Efficacy in Modifying Plasma Lipoproteins and Adverse Event Profile in 8245 Patients with Moderate Hypercholesterolemia. Archives of Internal Medicine, 151, 43-49. https://doi.org/10.1161/CIRCULATIONAHA.106.671016
|
[141]
|
Knopp, R.H. (1999) Drug Treatment of Lipid Disorders. New England Journal of Medicine, 341, 498-511. https://doi.org/10.1056/NEJM199908123410707
|
[142]
|
O’Gorman, C.S., Higgins, M.F. and O’Neill, M.B. (2009) Systematic Review and Metaanalysis of Statins for Heterozygous Familial Hypercholesterolemia in Children: Evaluation of Cholesterol Changes and Side Effects. Pediatric Cardiology, 30, 482-489. https://doi.org/10.1007/s00246-008-9364-3
|
[143]
|
Avis, H.J., Vissers, M.N., Stein, E.A., Wijburg, F.A., Trip, M.D., Kastelein, J.J.P., et al. (2007) A Systematic Review and Meta-Analysis of Statin Therapy in Children with Familial Hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 1803-1810. https://doi.org/10.1161/ATVBAHA.107.145151
|
[144]
|
Wiegman, A., Hutten, B.A., de Groot, E., Rodenburg, J., Bakker, H.D., Büller, H.R., et al. (2004) Efficacy and Safety of Statin Therapy in Children with Familial Hypercholesterolemia: A Randomized Controlled Trial. JAMA, 292, 331-337. https://doi.org/10.1001/jama.292.3.331
|
[145]
|
Stein, E.A., Marais, A.D., Szamosi, T., Raal, F.J., Schurr, D., Urbina, E.M., et al. (2010) Colesevelam Hydrochloride: Efficacy and Safety in Pediatric Subjects with Heterozygous Familial Hypercholesterolemia. Journal of Pediatrics, 156 231-236. https://doi.org/10.1016/j.jpeds.2009.08.037
|
[146]
|
van der Graaf, A., Cuffie-Jackson, C., Vissers, M.N,. Trip, M.D., Gagné, C., Shi, G., et al. (2008) Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents with Heterozygous Familial Hypercholesterolemia. Journal of the American College of Cardiology, 52, 1421-1429. https://doi.org/10.1016/j.jacc.2008.09.002
|